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〈ノート〉可溶化へスぺリジンによるリウマチモデルマウスの症状改善作⽤
https://kindai.repo.nii.ac.jp/records/20939
https://kindai.repo.nii.ac.jp/records/209395f594620-eccc-4009-9a8e-27ad2c66249b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00064044-20200331-0024.pdf (593.7 kB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||
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| 公開日 | 2020-06-19 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | 〈ノート〉可溶化へスぺリジンによるリウマチモデルマウスの症状改善作⽤ | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | 〈Notes〉Effect of hesperidin solubilized with its glucoside on improvement of rheumatoid arthritis in mice. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 著者 |
⽶⾕, 俊
× ⽶⾕, 俊
× 川⼝, 基⼀郎
× 熊沢, 義雄
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| 言語 | ||||||||||||||||||
| 言語 | jpn | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | α-glucosylhesperidin, hesperidin, rheumatoid arthritis, solubilization, transglycosylation | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||
| 著者(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | Kometani,Takashi | |||||||||||||||||
| 著者(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | Kawaguchi,Kiichirou | |||||||||||||||||
| 著者(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | Kumazawa,Yoshio | |||||||||||||||||
| 著者 所属 | ||||||||||||||||||
| 値 | 近畿⼤学農学部⾷品栄養学科: 近畿⼤学アグリ技術⾰新研究所: 近畿⼤学アンチエイジングセンター | |||||||||||||||||
| 著者 所属 | ||||||||||||||||||
| 値 | いわき明星⼤学; 名誉教授 | |||||||||||||||||
| 著者 所属 | ||||||||||||||||||
| 値 | 株式会社Vino Science Japan: 北⾥⼤学; 元教授 | |||||||||||||||||
| 著者所属(翻訳) | ||||||||||||||||||
| 値 | Department of Food Science and Nutrition, Faculty of Agriculture, Kindai University: Agricultural Technology and Innovation Research Institute, Kindai University: Anti-Aging Center, Kindai University | |||||||||||||||||
| 著者所属(翻訳) | ||||||||||||||||||
| 値 | Iwaki Meisei University; professor emeritus | |||||||||||||||||
| 著者所属(翻訳) | ||||||||||||||||||
| 値 | Vino Science Japan Co. Ltd.,: Kitasato Univversity; Former professor | |||||||||||||||||
| 版 | ||||||||||||||||||
| 出版タイプ | NA | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||||||||||
| 出版者 名前 | ||||||||||||||||||
| 出版者 | 近畿大学農学部 | |||||||||||||||||
| 書誌情報 |
近畿大学農学部紀要 en : MEMOIRS OF THE FACULTY OF AGRICULTURE OF KINDAI UNIVERSITY 号 53, p. 24-33, 発行日 2020-03-31 |
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| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 21896267 | |||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | [Synopsis] Since the functionalities of foods were first advocated from Japan in the 1980s, enormous research has been carried out for about 40 years. As a result, a great deal of research results have been obtained, and many have been put into practical use by utilizing the system of functional foods with health claim. However, the discovery of a novel bioactive substance from nature is considered to have been reaching its limit. The purpose of this study was to examine whether a novel solubilized compound, which has not been utilized due to their low solubility and poor bioavailability, could be available. α-Glucosylhesperidin (enzymatically glucosylated hesperidin; Hsp-G) has a micelle-like structure in an aqueous solution, and may be solubilized by incorporating a poorly soluble compound into its hydrophobic central part. Therefore, hesperidin (Hsp), which is hardly soluble in water, was solubilized with Hsp-G and orally administered to mouse models of rheumatoid arthritis. As a result, Hsp solubilized with Hsp-G was able to improve rheumatic symptoms even at a concentration at which no physiological activity was exhibited by Hsp or Hsp-G alone. Thus, bioactive substances solubilized with Hsp-G may be a practical applicability such as diet supplement in the future. | |||||||||||||||||
| フォーマット | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||
