@article{oai:kindai.repo.nii.ac.jp:00020939,
 author = {⽶⾕, 俊 and 川⼝, 基⼀郎 and 熊沢, 義雄},
 issue = {53},
 journal = {近畿大学農学部紀要, MEMOIRS OF THE FACULTY OF AGRICULTURE OF KINDAI UNIVERSITY},
 month = {Mar},
 note = {[Synopsis] Since the functionalities of foods were first advocated from Japan in the 1980s, enormous research has been carried out for about 40 years. As a result, a great deal of research results have been obtained, and many have been put into practical use by utilizing the system of functional foods with health claim. However, the discovery of a novel bioactive substance from nature is considered to have been reaching its limit. The purpose of this study was to examine whether a novel solubilized compound, which has not been utilized due to their low solubility and poor bioavailability, could be available. α-Glucosylhesperidin (enzymatically glucosylated hesperidin; Hsp-G) has a micelle-like structure in an aqueous solution, and may be solubilized by incorporating a poorly soluble compound into its hydrophobic central part. Therefore, hesperidin (Hsp), which is hardly soluble in water, was solubilized with Hsp-G and orally administered to mouse models of rheumatoid arthritis. As a result, Hsp solubilized with Hsp-G was able to improve rheumatic symptoms even at a concentration at which no physiological activity was exhibited by Hsp or Hsp-G alone. Thus, bioactive substances solubilized with Hsp-G may be a practical applicability such as diet supplement in the future., application/pdf},
 pages = {24--33},
 title = {〈ノート〉可溶化へスぺリジンによるリウマチモデルマウスの症状改善作⽤},
 year = {2020},
 yomi = {コメタニ, タカシ and カワグチ, キイチロウ and クマザワ, ヨシオ}
}