{"created":"2023-06-20T16:48:54.611820+00:00","id":20939,"links":{},"metadata":{"_buckets":{"deposit":"c0f1e0e6-5775-41fe-beef-2bd1527f12c5"},"_deposit":{"created_by":3,"id":"20939","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20939"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020939","sets":["14:923:1379:4586"]},"author_link":["35718","35717","35716"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"53","bibliographicPageEnd":"33","bibliographicPageStart":"24","bibliographic_titles":[{"bibliographic_title":"近畿大学農学部紀要"},{"bibliographic_title":"MEMOIRS OF THE FACULTY OF AGRICULTURE OF KINDAI UNIVERSITY","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Synopsis] Since the functionalities of foods were first advocated from Japan in the 1980s, enormous research has been carried out for about 40 years. As a result, a great deal of research results have been obtained, and many have been put into practical use by utilizing the system of functional foods with health claim. However, the discovery of a novel bioactive substance from nature is considered to have been reaching its limit. The purpose of this study was to examine whether a novel solubilized compound, which has not been utilized due to their low solubility and poor bioavailability, could be available. α-Glucosylhesperidin (enzymatically glucosylated hesperidin; Hsp-G) has a micelle-like structure in an aqueous solution, and may be solubilized by incorporating a poorly soluble compound into its hydrophobic central part. Therefore, hesperidin (Hsp), which is hardly soluble in water, was solubilized with Hsp-G and orally administered to mouse models of rheumatoid arthritis. As a result, Hsp solubilized with Hsp-G was able to improve rheumatic symptoms even at a concentration at which no physiological activity was exhibited by Hsp or Hsp-G alone. Thus, bioactive substances solubilized with Hsp-G may be a practical applicability such as diet supplement in the future.","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学農学部"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21896267","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kometani,Takashi"},{"subitem_text_language":"en","subitem_text_value":" Kawaguchi,Kiichirou"},{"subitem_text_language":"en","subitem_text_value":"Kumazawa,Yoshio"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿⼤学農学部⾷品栄養学科: 近畿⼤学アグリ技術⾰新研究所: 近畿⼤学アンチエイジングセンター"},{"subitem_text_value":"いわき明星⼤学; 名誉教授"},{"subitem_text_value":"株式会社Vino Science Japan: 北⾥⼤学;  元教授"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Food Science and Nutrition, Faculty of Agriculture, Kindai University: Agricultural Technology and Innovation Research Institute, Kindai University: Anti-Aging Center, Kindai University"},{"subitem_text_value":"Iwaki Meisei University; professor emeritus"},{"subitem_text_value":"Vino Science Japan Co. Ltd.,: Kitasato Univversity; Former professor"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"⽶⾕, 俊"},{"creatorName":"コメタニ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川⼝, 基⼀郎"},{"creatorName":"カワグチ, キイチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"熊沢, 義雄"},{"creatorName":"クマザワ, ヨシオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-19"}],"displaytype":"detail","filename":"AN00064044-20200331-0024.pdf","filesize":[{"value":"593.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00064044-20200331-0024.pdf","url":"https://kindai.repo.nii.ac.jp/record/20939/files/AN00064044-20200331-0024.pdf"},"version_id":"f99e15e7-5512-4236-9565-78606d832a2e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α-glucosylhesperidin","subitem_subject_scheme":"Other"},{"subitem_subject":"hesperidin","subitem_subject_scheme":"Other"},{"subitem_subject":"rheumatoid arthritis","subitem_subject_scheme":"Other"},{"subitem_subject":"solubilization","subitem_subject_scheme":"Other"},{"subitem_subject":"transglycosylation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈ノート〉可溶化へスぺリジンによるリウマチモデルマウスの症状改善作⽤","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈ノート〉可溶化へスぺリジンによるリウマチモデルマウスの症状改善作⽤"},{"subitem_title":"〈Notes〉Effect of hesperidin solubilized with its glucoside on improvement of rheumatoid arthritis in mice.","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["4586"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-06-19"},"publish_date":"2020-06-19","publish_status":"0","recid":"20939","relation_version_is_last":true,"title":["〈ノート〉可溶化へスぺリジンによるリウマチモデルマウスの症状改善作⽤"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T20:04:32.617846+00:00"}