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MS疾患モデルでのTh17/CD8+ T細胞間の新規コミュニケーションと併用療法
https://kindai.repo.nii.ac.jp/records/2000403
https://kindai.repo.nii.ac.jp/records/2000403f7f9816c-e32c-4383-a452-007ea11e010f
名前 / ファイル | ライセンス | アクション |
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Item type | 報告書 / report(1) | |||||
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公開日 | 2023-11-15 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | MS疾患モデルでのTh17/CD8+ T細胞間の新規コミュニケーションと併用療法 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Interactions between Th17 and CD8+ T cells in animal models of multiple sclerosis | |||||
研究代表者 |
佐藤, 文孝
× 佐藤, 文孝 |
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言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | 動物モデル, Th17細胞, ピコルナウイルス科 IgA |
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内容記述 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 本研究では,ヒト多発性硬化症(MS)の中枢神経系(CNS)病理像と同様にヘルパーT(Th)17細胞とCD8+T細胞の浸潤を伴うタイラーウイルス誘導性脳脊髄炎(TMEV-IDD)を用い,MS病態の解明を行った。Th17細胞を増強するとTMEV-IDDが軽減し,かつCD8+T細胞関連の遺伝子発現がCNS内で減少した。またこの一連の研究を通して,IgA抗体がCNS内に沈着しているのを見出した。近年、IgA産生B細胞の浸潤がMSでも報告されており,本成果からMS病態におけるTh17細胞-CD8+T細胞-IgA抗体による新規のコミュニケーションが明らかとなり,新たな治療法の開発へつながる可能性を示した。 | |||||
言語 | ja | |||||
内容記述 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Multiple sclerosis (MS) is an immune-mediated disease in the central nervous system (CNS). Although helper T (Th) 17 cells have been suggested to play pathogenic roles in MS, the precise pathomechanisms are unclear. We have used a viral model of MS, Theiler’s murine encephalomyelitis virus (TMEV) infection in mice, in which we can see infiltration of Th17 and CD8+T cells in the CNS that resembles MS neuropathologically. In this study, using the viral model, we aimed to determine the pathogenesis of MS by treating mice with a Th17 modulator, curdlan. Compared with control mice, curdlan-treated mice had significantly less severe clinical signs with decreased levels of CD8+ T cells and granzyme B in the CNS. We also found lower levels of IgA deposition in the CNS demyelinating lesions in curdlan-treated mice. Since IgA-producing B cells have been detected in the CNS of MS patients, our findings suggest the novel interactions among Th17, CD8+ T-cell, and IgA responses in MS. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究分野:神経免疫学 | |||||
言語 | ja | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_93fc | |||||
資源タイプ | report | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
助成情報 | ||||||
助成機関名 | 独立行政法人日本学術振興会 | |||||
言語 | ja | |||||
助成機関名 | Japan Society for the Promotion of Science | |||||
言語 | en | |||||
研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07433/ | |||||
研究課題番号 | 20K07433 | |||||
研究課題名 | MS疾患モデルでのTh17/CD8+ T細胞間の新規コミュニケーションと併用療法 | |||||
言語 | ja | |||||
研究課題名 | Interactions between Th17 and CD8+ T cells in animal models of multiple sclerosis | |||||
言語 | en | |||||
書誌情報 |
ja : 科学研究費助成事業研究成果報告書 (2022) ページ数 9 |