{"created":"2023-11-15T07:17:14.106411+00:00","id":2000403,"links":{},"metadata":{"_buckets":{"deposit":"10e3cd45-6cd1-4548-888b-497f89e77dda"},"_deposit":{"created_by":42,"id":"2000403","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000403"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000403","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"9","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"佐藤, 文孝","creatorNameLang":"ja"},{"creatorName":"Sato, Fumitaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30779327","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究では，ヒト多発性硬化症(MS)の中枢神経系(CNS)病理像と同様にヘルパーT(Th)17細胞とCD8+T細胞の浸潤を伴うタイラーウイルス誘導性脳脊髄炎(TMEV-IDD)を用い，MS病態の解明を行った。Th17細胞を増強するとTMEV-IDDが軽減し，かつCD8+T細胞関連の遺伝子発現がCNS内で減少した。またこの一連の研究を通して，IgA抗体がCNS内に沈着しているのを見出した。近年、IgA産生B細胞の浸潤がMSでも報告されており，本成果からMS病態におけるTh17細胞－CD8+T細胞－IgA抗体による新規のコミュニケーションが明らかとなり，新たな治療法の開発へつながる可能性を示した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Multiple sclerosis (MS) is an immune-mediated disease in the central nervous system (CNS). Although helper T (Th) 17 cells have been suggested to play pathogenic roles in MS, the precise pathomechanisms are unclear. We have used a viral model of MS, Theiler’s murine encephalomyelitis virus (TMEV) infection in mice, in which we can see infiltration of Th17 and CD8+T cells in the CNS that resembles MS neuropathologically. In this study, using the viral model, we aimed to determine the pathogenesis of MS by treating mice with a Th17 modulator, curdlan. Compared with control mice, curdlan-treated mice had significantly less severe clinical signs with decreased levels of CD8+ T cells and granzyme B in the CNS. We also found lower levels of IgA deposition in the CNS demyelinating lesions in curdlan-treated mice. Since IgA-producing B cells have been detected in the CNS of MS patients, our findings suggest the novel interactions among Th17, CD8+ T-cell, and IgA responses in MS.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：神経免疫学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07433seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000403/files/20K07433seika.pdf"},"version_id":"af5d24a5-4a7e-45b0-b766-af4f265a1189"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07433","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07433/"},"subitem_award_titles":[{"subitem_award_title":"MS疾患モデルでのTh17／CD8+ T細胞間の新規コミュニケーションと併用療法","subitem_award_title_language":"ja"},{"subitem_award_title":"Interactions between Th17 and CD8+ T cells in animal models of multiple sclerosis","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"動物モデル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Th17細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ピコルナウイルス科","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"IgA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MS疾患モデルでのTh17／CD8+ T細胞間の新規コミュニケーションと併用療法","subitem_title_language":"ja"},{"subitem_title":"Interactions between Th17 and CD8+ T cells in animal models of multiple sclerosis","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"MS疾患モデルでのTh17／CD8+ T細胞間の新規コミュニケーションと併用療法","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000403","relation_version_is_last":true,"title":["MS疾患モデルでのTh17／CD8+ T細胞間の新規コミュニケーションと併用療法"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-02-09T05:16:33.354291+00:00"}