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治療抵抗性慢性骨髄性白血病における耐性因子の同定と新規耐性克服法の開発
https://kindai.repo.nii.ac.jp/records/2000306
https://kindai.repo.nii.ac.jp/records/20003064ff70a0c-0ed5-477a-a26f-adede680a6ea
名前 / ファイル | ライセンス | アクション |
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Item type | 報告書 / report(1) | |||||
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公開日 | 2023-11-08 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 治療抵抗性慢性骨髄性白血病における耐性因子の同定と新規耐性克服法の開発 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Identification of resistance factors and development of novel strategy to overcome resistance in treatment-resistant chronic myeloid leukemia | |||||
研究代表者 |
西田, 升三
× 西田, 升三 |
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研究協力者 |
椿, 正寛
× 椿, 正寛× 武田, 朋也 |
|||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | 慢性骨髄性白血病, BCR-ABL1阻害薬 | |||||
内容記述 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | ヒト慢性骨髄性白血病細胞においてBCR-ABL1阻害薬耐性細胞を樹立し、耐性獲得機序の解析を行い、バイパスシグナル伝達経路活性化が関与することを見出した。さらに、このバイパス経路を阻害する分子標的薬によりBCR-ABL1阻害薬耐性を克服することを明らかにした。以上の結果は、臨床におけるBCR-ABL1阻害薬耐性慢性骨髄性白血病出現時における治療に貢献できる可能性が考えられる。なお、本研究成果は主な発表論文の項に全てまとめてある。 | |||||
言語 | ja | |||||
内容記述 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We established BCR-ABL1 inhibitor-resistant cells in human chronic myeloid leukemia cells, analyzed the mechanism of resistance acquisition, and found that activation of the bypass signaling pathway is involved. Furthermore, we found that BCR-ABL1 inhibitor resistance can be overcome by molecularly targeted drugs that inhibit this bypass pathway. These results may contribute to the clinical treatment of BCR-ABL1 inhibitor-resistant chronic myeloid leukemia when it emerges. The results of this study are summarized in the main publications section. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究分野:薬物治療学 | |||||
言語 | ja | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_93fc | |||||
資源タイプ | report | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
助成情報 | ||||||
助成機関名 | 独立行政法人日本学術振興会 | |||||
言語 | ja | |||||
助成機関名 | Japan Society for the Promotion of Science | |||||
言語 | en | |||||
研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07145/ | |||||
研究課題番号 | 20K07145 | |||||
研究課題名 | 治療抵抗性慢性骨髄性白血病における耐性因子の同定と新規耐性克服法の開発 | |||||
言語 | ja | |||||
研究課題名 | Identification of resistance factors and development of novel strategy to overcome resistance in treatment-resistant chronic myeloid leukemia | |||||
言語 | en | |||||
書誌情報 |
ja : 科学研究費助成事業研究成果報告書 (2022) ページ数 11 |