{"created":"2023-11-08T01:37:18.788046+00:00","id":2000306,"links":{},"metadata":{"_buckets":{"deposit":"f81ac0fd-e83b-4027-aed0-f9893e419be5"},"_deposit":{"created_by":42,"id":"2000306","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000306"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000306","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378692288":{"attribute_name":"研究協力者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"椿, 正寛","creatorNameLang":"ja"},{"creatorName":"TSUBAKI, Masanobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30434856","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"武田, 朋也","creatorNameLang":"ja"},{"creatorName":"TAKEDA, Tomoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20734031","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"11","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"西田, 升三","creatorNameLang":"ja"},{"creatorName":"NISHIDA, Shozo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40208187","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ヒト慢性骨髄性白血病細胞においてBCR-ABL1阻害薬耐性細胞を樹立し、耐性獲得機序の解析を行い、バイパスシグナル伝達経路活性化が関与することを見出した。さらに、このバイパス経路を阻害する分子標的薬によりBCR-ABL1阻害薬耐性を克服することを明らかにした。以上の結果は、臨床におけるBCR-ABL1阻害薬耐性慢性骨髄性白血病出現時における治療に貢献できる可能性が考えられる。なお、本研究成果は主な発表論文の項に全てまとめてある。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"We established BCR-ABL1 inhibitor-resistant cells in human chronic myeloid leukemia cells, analyzed the mechanism of resistance acquisition, and found that activation of the bypass signaling pathway is involved. Furthermore, we found that BCR-ABL1 inhibitor resistance can be overcome by molecularly targeted drugs that inhibit this bypass pathway. These results may contribute to the clinical treatment of BCR-ABL1 inhibitor-resistant chronic myeloid leukemia when it emerges. The results of this study are summarized in the main publications section.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：薬物治療学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07145seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000306/files/20K07145seika.pdf"},"version_id":"ff382d06-48f9-4ab5-bf13-342734717831"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07145","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07145/"},"subitem_award_titles":[{"subitem_award_title":"治療抵抗性慢性骨髄性白血病における耐性因子の同定と新規耐性克服法の開発","subitem_award_title_language":"ja"},{"subitem_award_title":"Identification of resistance factors and development of novel strategy to overcome resistance in treatment-resistant chronic myeloid leukemia","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"慢性骨髄性白血病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"BCR-ABL1阻害薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"治療抵抗性慢性骨髄性白血病における耐性因子の同定と新規耐性克服法の開発","subitem_title_language":"ja"},{"subitem_title":"Identification of resistance factors and development of novel strategy to overcome resistance in treatment-resistant chronic myeloid leukemia","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"治療抵抗性慢性骨髄性白血病における耐性因子の同定と新規耐性克服法の開発","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000306","relation_version_is_last":true,"title":["治療抵抗性慢性骨髄性白血病における耐性因子の同定と新規耐性克服法の開発"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-02-09T05:49:22.189075+00:00"}