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<Original Papers>Anti-inflammatory effects of Volatile Compound of Macrophage Migration Inhibitory Factor (MIF) Induction of Inflammatory in Macrophage Cell
https://kindai.repo.nii.ac.jp/records/7300
https://kindai.repo.nii.ac.jp/records/730099254d95-fc9e-4333-ab97-5bb7212b7386
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063799-20101220-0001.pdf (2.9 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||
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| 公開日 | 2011-02-21 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | <Original Papers>Anti-inflammatory effects of Volatile Compound of Macrophage Migration Inhibitory Factor (MIF) Induction of Inflammatory in Macrophage Cell | |||||||||||||||||
| 著者 |
OTSUBO, Eiji
× OTSUBO, Eiji
× NISHIHIRA, Jun
× NOMURA, Masato
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| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | proinflammatory cytokines, suppression, volatile compounds, macrophage cell, macrophage migration inhibitory factor | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||
| 著者(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | 大坪, 英二 | |||||||||||||||||
| 著者(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | 西平, 順 | |||||||||||||||||
| 著者(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | 野村, 正人 | |||||||||||||||||
| 著者 所属 | ||||||||||||||||||
| 値 | Research Center, Tanabe Mitsubishi Pharmaceuticals, Inc. | |||||||||||||||||
| 著者 所属 | ||||||||||||||||||
| 値 | Department of Medical Management and Informatics, Hokkaido Information University. | |||||||||||||||||
| 著者 所属 | ||||||||||||||||||
| 値 | Department of Biotechnology and Chemistry, Faculty of Engineering, Kinki University. | |||||||||||||||||
| 著者所属(翻訳) | ||||||||||||||||||
| 値 | 田辺三菱製薬株式会社 | |||||||||||||||||
| 著者所属(翻訳) | ||||||||||||||||||
| 値 | 北海道情報大学経営情報学部医療情報学科 | |||||||||||||||||
| 著者所属(翻訳) | ||||||||||||||||||
| 値 | 近畿大学工学部生物化学工学科 | |||||||||||||||||
| 版 | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| 出版者 名前 | ||||||||||||||||||
| 出版者 | 近畿大学工学部 | |||||||||||||||||
| 書誌情報 |
近畿大学工学部研究報告 en : Research reports of the Faculty of Engineering, Kinki University 号 44, p. 1-7, 発行日 2010-12-01 |
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| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 0386491X | |||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | [Summary]Macrophage migration inhibitory factor (MIF) plays an important role in systemic local inflammatory and immune responses. Tumor necrosis factor-α (TNF-α)are major proinflammatory cytokines and is mainly products by monocytes and macrophages, and inducing the synthesis and release of many inflammatory mediators. It is involved in immune regulation, autoimmune diseases, and inflammation. Moreover, MIF is a counter regulator against corticosteroids. We previously assay that synthetic surfactant to inhibition of releases of proinflammatroy cytokines and then found the important characterization of releases of MIF. In this study, we tested to proinflammatory cytokines suppression of volatile compound to macrophage cells inducing MIF. As a result, carvone, eucarvone, karahanaenone, hinokitiol and a-camphorenaldhyde were inhibition to release of TNF-α from MIF-stimulated RAW 264.7 cells at concentration of 10μg/ml, respectively. Moreover, these compounds did not inhibit the release of TNF-α in THP-1 cells inducing LPS at tested concentrations. This result suggested that a specific pharmacological action should be involved in the inhibitory activity of these compounds. It seems that the compounds are direct acting MIF signal in cell. | |||||||||||||||||
| フォーマット | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||
