{"created":"2023-06-20T16:37:31.643833+00:00","id":7300,"links":{},"metadata":{"_buckets":{"deposit":"18c4e0ed-4464-48c5-9835-19f7217fc617"},"_deposit":{"created_by":3,"id":"7300","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"7300"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00007300","sets":["14:923:1711:1721","21:3039:3241:3285"]},"author_link":["12487","12489","12488"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"44","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"近畿大学工学部研究報告"},{"bibliographic_title":"Research reports of the Faculty of Engineering, Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Summary]Macrophage migration inhibitory factor (MIF) plays an important role in systemic local inflammatory and immune responses. Tumor necrosis factor-α (TNF-α)are major proinflammatory cytokines and is mainly products by monocytes and macrophages, and inducing the synthesis and release of many inflammatory mediators. It is involved in immune regulation, autoimmune diseases, and inflammation. Moreover, MIF is a counter regulator against corticosteroids. We previously assay that synthetic surfactant to inhibition of releases of proinflammatroy cytokines and then found the important characterization of releases of MIF. In this study, we tested to proinflammatory cytokines suppression of volatile compound to macrophage cells inducing MIF. As a result, carvone, eucarvone, karahanaenone, hinokitiol and a-camphorenaldhyde were inhibition to release of TNF-α from MIF-stimulated RAW 264.7 cells at concentration of 10μg/ml, respectively. Moreover, these compounds did not inhibit the release of TNF-α in THP-1 cells inducing LPS at tested concentrations. This result suggested that a specific pharmacological action should be involved in the inhibitory activity of these compounds. It seems that the compounds are direct acting MIF signal in cell.","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学工学部"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386491X","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"大坪, 英二"},{"subitem_text_language":"en","subitem_text_value":"西平, 順"},{"subitem_text_language":"en","subitem_text_value":"野村, 正人"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"Research Center, Tanabe Mitsubishi Pharmaceuticals, Inc."},{"subitem_text_value":"Department of Medical Management and Informatics, Hokkaido Information University."},{"subitem_text_value":"Department of Biotechnology and Chemistry, Faculty of Engineering, Kinki University."}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"田辺三菱製薬株式会社"},{"subitem_text_value":"北海道情報大学経営情報学部医療情報学科"},{"subitem_text_value":"近畿大学工学部生物化学工学科"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OTSUBO,  Eiji"},{"creatorName":"オオツボ, エイジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIHIRA,  Jun"},{"creatorName":"ニシヒラ, ジュン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NOMURA,  Masato"},{"creatorName":"ノムラ, マサト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AN00063799-20101220-0001.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00063799-20101220-0001.pdf","url":"https://kindai.repo.nii.ac.jp/record/7300/files/AN00063799-20101220-0001.pdf"},"version_id":"d980813a-0130-41eb-ad15-5029c2cd4a1d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"proinflammatory cytokines","subitem_subject_scheme":"Other"},{"subitem_subject":"suppression","subitem_subject_scheme":"Other"},{"subitem_subject":"volatile compounds","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage cell","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage migration inhibitory factor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Original Papers>Anti-inflammatory effects of Volatile Compound of Macrophage Migration Inhibitory Factor (MIF) Induction of Inflammatory in Macrophage Cell","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Original Papers>Anti-inflammatory effects of Volatile Compound of Macrophage Migration Inhibitory Factor (MIF) Induction of Inflammatory in Macrophage Cell"}]},"item_type_id":"2","owner":"3","path":["1721","3285"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-02-21"},"publish_date":"2011-02-21","publish_status":"0","recid":"7300","relation_version_is_last":true,"title":["<Original Papers>Anti-inflammatory effects of Volatile Compound of Macrophage Migration Inhibitory Factor (MIF) Induction of Inflammatory in Macrophage Cell"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T00:19:01.515009+00:00"}