WEKO3
アイテム
MINORITY REPORT: FUNCTIONAL CHARACTERIZATION OF A SUBSET OF EXTREMELY ALKALINE PROTEINS IN THE HUMAN PROTEOME
https://kindai.repo.nii.ac.jp/records/22754
https://kindai.repo.nii.ac.jp/records/227543560aa0b-7205-4ee6-a607-8a0838ff062e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA11574630-20220331-0001.pdf (1.5 MB)
|
|
| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2022-05-19 | |||||||||
| タイトル | ||||||||||
| タイトル | MINORITY REPORT: FUNCTIONAL CHARACTERIZATION OF A SUBSET OF EXTREMELY ALKALINE PROTEINS IN THE HUMAN PROTEOME | |||||||||
| 言語 | en | |||||||||
| 著者 |
Tokmakov, Alexander A.
× Tokmakov, Alexander A.
× Kurotani, Atsushi
|
|||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | protein pI, human proteome, multimodality, extremely alkaline proteins, protein function | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 著者所属(翻訳) | ||||||||||
| 値 | Institute of Advanced Technology, Faculty of Biology-Oriented Science and Technology, KinDai University | |||||||||
| 著者所属(翻訳) | ||||||||||
| 値 | Center for Sustainable Resource Science, RIKEN Yokohama Institute | |||||||||
| 版 | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学先端技術総合研究所 | |||||||||
| 書誌情報 |
近畿大学先端技術総合研究所紀要 en : Memoirs of Institute of Advanced Technology, Kindai University 号 27, p. 1-6, 発行日 2022-03-31 |
|||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 13468693 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | [Abstract] Whole-proteome distributions of the protein isoelectric point (pI) are not Gaussian but rather multimodal. In the present study, we performed functional characterization of an extremely alkaline protein modality (pI>11.5, n=503) in the human proteome. Here, we report that the majority of the extremely alkaline proteins (69%), which have predominantly nuclear or mitochondrial localization (80%), are involved in information storage and processing. These proteins were further classified in the functional groups of “Translation, ribosomal structure and biogenesis”, “RNA processing and modification”, and “Chromatin structure and dynamic”, according to the classification of Eukaryotic Orthologous Groups, KOGs. In addition, a lot of nuclear proteins in the analyzed subset (63%) bear the nucleolar localization signal. These data indicate that many of the extremely alkaline proteins localize to the nucleolus and are involved in ribosome biogenesis and RNA processing. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Original Paper | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
