@article{oai:kindai.repo.nii.ac.jp:00022754,
 author = {Tokmakov, Alexander A. and Kurotani, Atsushi},
 issue = {27},
 journal = {近畿大学先端技術総合研究所紀要, Memoirs of Institute of Advanced Technology, Kindai University},
 month = {Mar},
 note = {[Abstract] Whole-proteome distributions of the protein isoelectric point (pI) are not Gaussian but rather multimodal. In the present study, we performed functional characterization of an extremely alkaline protein modality (pI>11.5, n=503) in the human proteome. Here, we report that the majority of the extremely alkaline proteins (69%), which have predominantly nuclear or mitochondrial localization (80%), are involved in information storage and processing. These proteins were further classified in the functional groups of “Translation, ribosomal structure and biogenesis”, “RNA processing and modification”, and “Chromatin structure and dynamic”, according to the classification of Eukaryotic Orthologous Groups, KOGs. In addition, a lot of nuclear proteins in the analyzed subset (63%) bear the nucleolar localization signal. These data indicate that many of the extremely alkaline proteins localize to the nucleolus and are involved in ribosome biogenesis and RNA processing., Original Paper, application/pdf},
 pages = {1--6},
 title = {MINORITY REPORT: FUNCTIONAL CHARACTERIZATION OF A SUBSET OF EXTREMELY ALKALINE PROTEINS IN THE HUMAN PROTEOME},
 year = {2022}
}