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〈Review〉アルギニル化
https://kindai.repo.nii.ac.jp/records/20094
https://kindai.repo.nii.ac.jp/records/200946ad1b2d1-8182-4e5f-a509-5320663e6e5a
名前 / ファイル | ライセンス | アクション |
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AA11574630-20190331-0019.pdf (3.8 MB)
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Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-04-18 | |||||
タイトル | ||||||
タイトル | 〈Review〉アルギニル化 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Arginylation | |||||
著者 |
美濃部, 晃平
× 美濃部, 晃平× 黒坂, 哲 |
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言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | 翻訳後修飾, アルギニル化, arginylation, アルギニン転移酵素, ATEI posttranslational modification, arginylation, arginyltransferase, ATE1 |
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資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者(英) | ||||||
en | ||||||
Minobe,Kohei | ||||||
著者(英) | ||||||
en | ||||||
Kurosaka,Satoshi | ||||||
著者 所属 | ||||||
近畿大学生物理工学研究科生物工学専攻 | ||||||
著者 所属 | ||||||
近畿大学先端技術総合研究所 | ||||||
著者所属(翻訳) | ||||||
Graduate school of Biology-Oriented Science and Technology, Kindai University | ||||||
著者所属(翻訳) | ||||||
Institute of Advanced Technology, Kindai University | ||||||
版 | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
出版者 名前 | ||||||
出版者 | 近畿大学先端技術総合研究所 | |||||
書誌情報 |
近畿大学先端技術総合研究所紀要 en : Memoirs of Institute of Advanced Technology, Kindai University 号 24, p. 19-24, 発行日 2019-03-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13468693 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | [要旨]タンパク質の多くはゲノム上の遺伝子が転写・翻訳された後、様々な修飾を受け、その構造、局在、活性、他の分子との相互作用などが調節される。このような修飾を翻訳後修飾と呼び、リン酸化やアセチル化、ユビキチン化などが広く知られている。アルギニル化は、アルギニン転移酵素(ATE1)によってアルギニンがタンパク質に付加する翻訳後修飾である。アルギニル化は1960年代に発見され、2000年代になって生体におけるその機能の研究が進んできたが、いまだ未解明の部分が多い。本稿では、遺伝子改変マウスを用いた研究の成果を中心に、これまでにわかっているアルギニル化の機能について解説する。 The structure, localization, activity, and interaction of proteins are regulated by various modifications following translation. Those modifications, such as phosphorylation, acetylation, and ubiquitination for well-known examples, are called posttranslational modifications. A posttranslational modification, called “Arginylation”, is the addition of arginine to target proteins, mediated by arginyltransferase (ATE1) . Arginylation has been first reported in 1960s, and after decades of progress of researches on its functions in live cells/organisms, this posttranslational modification is still poorly understood. This review focuses on critical roles of arginylation, especially that are revealed in studies using gene modified mice. |
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フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |