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ハイスループットテクノロジーによる薬剤、および細胞スクリーニング
https://kindai.repo.nii.ac.jp/records/14957
https://kindai.repo.nii.ac.jp/records/14957f7c5bd0d-75ad-46f2-ac77-704b8a001475
| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2016-06-01 | |||||||||
| タイトル | ||||||||||
| タイトル | ハイスループットテクノロジーによる薬剤、および細胞スクリーニング | |||||||||
| タイトル | ||||||||||
| タイトル | Drug and cell screening using high-throughput technology | |||||||||
| 言語 | en | |||||||||
| 著者 |
森田, 資隆
× 森田, 資隆
|
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | 薬剤スクリーニング, 細胞スクリーニング, ハイスループット, ペプチド, 神経成長因子, 幹細胞 "drug screening, cell screening, high-throughput, peptidenerve growth factor, stem cell" |
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| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | metadata only access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||
| 著者(英) | ||||||||||
| en | ||||||||||
| Morita, Yasutaka | ||||||||||
| 著者 所属 | ||||||||||
| 近畿大学 | ||||||||||
| 著者所属(翻訳) | ||||||||||
| Kinki University | ||||||||||
| 版 | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学産業理工学部 | |||||||||
| 書誌情報 |
かやのもり：近畿大学産業理工学部研究報告 en : Reports of Faculty of Humanity-Oriented Science and Engineering, Kinki University 巻 9, 号 2, p. 1-6, 発行日 2008-12-10 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 13495801 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | "Abstract: Combining miniaturized technology with developments in automation, sensitive signal-detection, plate formats, automated compound-delivery and data management results in highly efficient, and cost-effective, integrated miniaturized ultra high-throughput screening systems. It is reported on the drug screening to find the nerve growth factor using high-throughput micro-chamber array chip. Phage display is an effective technique for the isolation of the peptides and proteins, that can bind to a specific molecule. This approach allows the use of chemicals in physiological conditions as the target, so phage display is suitable for the development of peptides that切nd to cell surface antigen, because native proteins can be used as the target in physiological conditions. We used the undifferentiated Pl9 embryonal carcinoma cells (P19 cells) as the model of stem cells, and the isolated peptides could bind to the undifferentiated P19 cells from phage display library. For selections of the phage, P19 cells were induced to differentiate into neurons by addition of retinoic acid. The differentiated P19 cells were used to deplete the library of non-specific phages. The isolated phage selectively binds to the undifferentiated P19 cells, and the phage bin小ng was inhibited by the free peptides." | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
