@article{oai:kindai.repo.nii.ac.jp:00014957,
 author = {森田,  資隆},
 issue = {2},
 journal = {かやのもり：近畿大学産業理工学部研究報告, Reports of Faculty of Humanity-Oriented Science and Engineering, Kinki University},
 month = {Dec},
 note = {"Abstract: Combining miniaturized technology with developments in automation, sensitive signal-detection, plate formats, automated compound-delivery and data management results in highly efficient, and cost-effective, integrated miniaturized ultra high-throughput screening systems. It is reported on the drug screening to find the nerve growth factor using high-throughput micro-chamber array chip. Phage display is an effective technique for the isolation of the peptides and proteins, that can bind to a specific molecule. This approach allows the use of chemicals in physiological conditions as the target, so phage display is suitable for the development of peptides that切nd to cell surface antigen, because native proteins can be used as the target in physiological conditions. We used the undifferentiated Pl9 embryonal carcinoma cells (P19 cells) as the model of stem cells, and the isolated peptides could bind to the undifferentiated P19 cells from phage display library. For selections of the phage, P19 cells were induced to differentiate into neurons by addition of retinoic acid. The differentiated P19 cells were used to deplete the library of non-specific phages. The isolated phage selectively binds to the undifferentiated P19 cells, and the phage bin小ng was inhibited by the free peptides.", application/pdf},
 pages = {1--6},
 title = {ハイスループットテクノロジーによる薬剤、および細胞スクリーニング},
 volume = {9},
 year = {2008},
 yomi = {モリタ, ヤスタカ}
}