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ループス腎炎に対する抗Kim-1抗体の治療効果について
https://kindai.repo.nii.ac.jp/records/14060
https://kindai.repo.nii.ac.jp/records/1406012899f56-8f02-4677-bc25-8de8780e487a
名前 / ファイル | ライセンス | アクション |
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Item type | 研究報告書 / Research Paper(1) | |||||
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公開日 | 2014-10-16 | |||||
タイトル | ||||||
タイトル | ループス腎炎に対する抗Kim-1抗体の治療効果について | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | The therapeutic effect of anti-Kim-1 antibody in lupus nephritis | |||||
著者 |
野﨑, 祐史
× 野﨑, 祐史 |
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言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | lupus nephritis, RMT1-10 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
著者(英) | ||||||
en | ||||||
NOZAKI, Yuji | ||||||
著者 所属 | ||||||
近畿大学医学部; 講師 | ||||||
著者 役割 | ||||||
研究代表者 | ||||||
著者 外部リンク | ||||||
関連名称 | http://kaken.nii.ac.jp/d/r/90411595.ja.html | |||||
版 | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 名前 | ||||||
出版者 | 近畿大学 | |||||
書誌情報 |
科学研究費助成事業研究成果報告書 (2013. ) p. 1-4, 発行日 2013-01-01 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 研究成果の概要(和文): Tim-1(Kim-1)はCD4+T細胞の免疫応答を調節し, 尿細管障害にて発現する. 今回, 抗Tim-1 抗体(RMT1-10)をループスモデルであるMRL-Faslprマウスに3ヶ月齢から16週間投与した. 結果, 生存率, リンパ節腫脹, 皮疹増悪は改善した. 腎機能, 蛋白尿, 抗DNA抗体産生, リンパ球浸潤程度は改善した. Th1/17免疫応答は低下したが, 制御性B/T細胞は増加した. RMT1-10治療群はまた, 糸球体免疫グロブリン・C3沈着, 細胞増殖・アポトーシスも抑制された. 尿中・尿細管Kim-1発現は低下し, 尿細管間質障害は改善した. RMT1-10は治療薬となりうる可能性が考えられた. 研究成果の概要(英文): The T-cell immunoglobulin mucin 1 (Tim-1), (Kim-1), modulates CD4+ T-cell responses and is also expressed by damaged proximal tubules. This study investigated the effects of an inhibitory anti-Tim-1 antibody (RMT1-10) in lupus-prone MRL-Faslpr mice. The mice were treated with RMT1-10 from 3 mo of age for 16 wk. RMT1-10 treatment significantly improved survival, limited the development of lymphadenopathy and skin lesions, preserved renal function and decreased proteinuria, reduced serum anti-DNA antibody levels, and attenuated renal leukocyte accumulation. Th1/Th17 cellular responses were reduced, but regulatory T/B cells were increased. RMT1-10 treatment also reduced glomerular immunoglobulin and C3 deposition and suppressed cellular proliferation and apoptosis. Urinary excretion and renal expression of Kim-1 was reduced, reflecting diminished interstitial injury. As RMT1-10 attenuated manipulating immune system Tim-1 may represent a therapeutic strategy in autoimmune diseases. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究種目:若手研究(B); 研究期間:2012~2013; 課題番号:24791012; 研究分野:医歯薬学; 科研費の分科・細目:内科系 臨床医学 膠原病・アレルギー内科学 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Research Paper | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |