{"created":"2023-06-20T16:43:13.966998+00:00","id":14060,"links":{},"metadata":{"_buckets":{"deposit":"996f84ee-385e-4aaa-8a07-7a89a41e260a"},"_deposit":{"created_by":3,"id":"14060","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14060"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00014060","sets":["14:2667:2671:2672"]},"author_link":["4001"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The therapeutic effect of anti-Kim-1 antibody in lupus nephritis"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文):  Tim-1(Kim-1)はCD4+T細胞の免疫応答を調節し, 尿細管障害にて発現する. 今回, 抗Tim-1 抗体(RMT1-10)をループスモデルであるMRL-Faslprマウスに3ヶ月齢から16週間投与した. 結果, 生存率, リンパ節腫脹, 皮疹増悪は改善した. 腎機能, 蛋白尿, 抗DNA抗体産生, リンパ球浸潤程度は改善した. Th1/17免疫応答は低下したが, 制御性Ｂ/Ｔ細胞は増加した. RMT1-10治療群はまた, 糸球体免疫グロブリン・C3沈着, 細胞増殖・アポトーシスも抑制された. 尿中・尿細管Kim-1発現は低下し, 尿細管間質障害は改善した. RMT1-10は治療薬となりうる可能性が考えられた.           研究成果の概要（英文): The T-cell immunoglobulin mucin 1 (Tim-1), (Kim-1), modulates CD4+ T-cell responses and is also expressed by damaged proximal tubules. This study investigated the effects of an inhibitory anti-Tim-1 antibody (RMT1-10) in lupus-prone MRL-Faslpr mice. The mice were treated with RMT1-10 from 3 mo of age for 16 wk. RMT1-10 treatment significantly improved survival, limited the development of lymphadenopathy and skin lesions, preserved renal function and decreased proteinuria, reduced serum anti-DNA antibody levels, and attenuated renal leukocyte accumulation. Th1/Th17 cellular responses were reduced, but regulatory T/B cells were increased. RMT1-10 treatment also reduced glomerular immunoglobulin and C3 deposition and suppressed cellular proliferation and apoptosis. Urinary excretion and renal expression of Kim-1 was reduced, reflecting diminished interstitial injury. As RMT1-10 attenuated manipulating immune system Tim-1 may represent a therapeutic strategy in autoimmune diseases.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2012～2013;   課題番号：24791012;   研究分野：医歯薬学;   科研費の分科・細目：内科系　臨床医学　膠原病・アレルギー内科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/90411595.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NOZAKI, Yuji"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野﨑,  祐史"},{"creatorName":"ノザキ, ユウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_24791012seika.pdf","filesize":[{"value":"329.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_24791012seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/14060/files/KAKEN_24791012seika.pdf"},"version_id":"5343465f-94ca-4078-bb14-ad13ae651e1c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lupus nephritis","subitem_subject_scheme":"Other"},{"subitem_subject":"RMT1-10","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ループス腎炎に対する抗Kｉｍ-１抗体の治療効果について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ループス腎炎に対する抗Kｉｍ-１抗体の治療効果について"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"14060","relation_version_is_last":true,"title":["ループス腎炎に対する抗Kｉｍ-１抗体の治療効果について"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:03:16.951490+00:00"}