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End joining activity of DNA double-strand breaks in the embryonic mouse brain
https://kindai.repo.nii.ac.jp/records/11087
https://kindai.repo.nii.ac.jp/records/11087e5cf2765-20d5-40bd-a683-df3080f8eb37
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN10074306-20080229-0027.pdf (1.5 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2010-08-06 | |||||||||
| タイトル | ||||||||||
| タイトル | End joining activity of DNA double-strand breaks in the embryonic mouse brain | |||||||||
| 言語 | en | |||||||||
| 著者 |
Fukushima, Nobuyuki
× Fukushima, Nobuyuki
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| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | DNA double strand breaks, DNA ligase, brain, development, neuronal survival | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 著者 所属 | ||||||||||
| 値 | RIST, Kinki University | |||||||||
| 版 | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学理工学総合研究所 | |||||||||
| 書誌情報 |
理工学総合研究所研究報告 en : Annual reports by Research Institute for Science and Technology 号 20, p. 27-33, 発行日 2008-02-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 09162054 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Double-strand breaks (DSBs) of DNA are introduced in neurons during embryonic brain development. Here I examine the DNA end joining activity to restore DSBs bearing distinct types of DNA ends in embryonic and adult brains. Embryonic brains contained the end joining activity for cohesive DNA ends. By contrast, adult brains showed no detectable end joining activity. The degree of the end joining activity seemed to be correlated with viability of neurons in culture. Thus, DNA repair for DSBs is likely to be involved in neuronal viability during brain development. | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
