| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2011-01-31 |
| タイトル |
|
|
タイトル |
[Reviews] Free radicals, antioxidants and cancer chemotherapy |
|
言語 |
en |
| 著者 |
Alexieva, Bistra
Markova, Tzvetanka
Nikolova, Elena
Aragane, Yoshinori
Higashino, Hideaki
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
oxidative stress, cancer, chemotherapeutic drugs, dietary antioxidants |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者所属(翻訳) |
|
|
|
Institute of Experimental Morphology and Anthropology with Museum, Bulgarian Academy of Sciences |
| 著者所属(翻訳) |
|
|
|
Department of Pharmacology, Medical University |
| 著者所属(翻訳) |
|
|
|
Department of Pharmacology, Medical University |
| 著者所属(翻訳) |
|
|
|
International Tougenkai Institute for Photo-and Immunotherapy of the skin |
| 著者所属(翻訳) |
|
|
|
Department of Pharmacology, Kinki University Faculty of Medicine |
| 版 |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 名前 |
|
|
出版者 |
The Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 35,
号 2,
p. 57-65,
発行日 2010-12-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Free radicals play a dual role as both beneficial and deleterious species, since they can be either helpful or harmful to the organism. They are products from normal cellular metabolism, or from external sources like pollution, medication, and radiation. The accumulation of excessive amount of free radicals in the body generates redox imbalance, a phenomenon referred to as oxidative stress. This deleterious process is involved in development of chronic and degenerative diseases such as cancer, rheumatoid arthritis, cardiovascular and neurodegenerative illnesses. In order to check the activities of free radicals in vivo, antioxidant systems have evolved, either naturally generated (endogenous antioxidants), or externally supplied through foods (exogenous antioxidants). This review deals with free radicals and their beneficial and deleterious effect on cellular activities, role of antioxidants (glutathione) in the maintenance of cellular redox homeostasis ; atention is focused on free radical-linked pathogenesis of cancer, and a discussion is also devoted to antioxidant supplementation in cancer patients undergoing chemotherapy. |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20101200-0057.pdf (3.8 MB)
