{"created":"2023-06-20T16:40:17.554779+00:00","id":10516,"links":{},"metadata":{"_buckets":{"deposit":"51fe7c9a-e834-4b02-93b2-97f0d0fea73f"},"_deposit":{"created_by":3,"id":"10516","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10516"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00010516","sets":["14:923:1519:1539","21:3039:3477:3482"]},"author_link":["20338","20341","20342","20340","20339"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"65","bibliographicPageStart":"57","bibliographicVolumeNumber":"35","bibliographic_titles":[{},{"bibliographic_title":"ACTA MEDICA KINKI UNIVERSITY","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Abstract] Free radicals play a dual role as both beneficial and deleterious species, since they can be either helpful or harmful to the organism. They are products from normal cellular metabolism, or from external sources like pollution, medication, and radiation. The accumulation of excessive amount of free radicals in the body generates redox imbalance, a phenomenon referred to as oxidative stress. This deleterious process is involved in development of chronic and degenerative diseases such as cancer, rheumatoid arthritis, cardiovascular and neurodegenerative illnesses. In order to check the activities of free radicals in vivo, antioxidant systems have evolved, either naturally generated (endogenous antioxidants), or externally supplied through foods  (exogenous antioxidants). This review deals with free radicals and their beneficial and deleterious effect on cellular activities, role of antioxidants (glutathione) in the maintenance of cellular redox homeostasis ; atention is focused on free radical-linked pathogenesis of cancer, and a discussion is also devoted to antioxidant supplementation in cancer patients undergoing chemotherapy.","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"The Kinki University Medical Association"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866092","subitem_source_identifier_type":"ISSN"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Institute of Experimental Morphology and Anthropology with Museum, Bulgarian Academy of Sciences"},{"subitem_text_value":"Department of Pharmacology, Medical University"},{"subitem_text_value":"Department of Pharmacology, Medical University"},{"subitem_text_value":"International Tougenkai Institute for Photo-and Immunotherapy of the skin"},{"subitem_text_value":"Department of Pharmacology, Kinki University Faculty of Medicine"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Alexieva, Bistra"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Markova, Tzvetanka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nikolova, Elena"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aragane, Yoshinori"},{"creatorName":"アラガネ, ヨシノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashino, Hideaki"},{"creatorName":"ヒガシノ, ヒデアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AA0050842X-20101200-0057.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AA0050842X-20101200-0057.pdf","url":"https://kindai.repo.nii.ac.jp/record/10516/files/AA0050842X-20101200-0057.pdf"},"version_id":"ed0f53c7-2393-44d7-a7f8-8a0b0b031af5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chemotherapeutic drugs","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dietary antioxidants","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"[Reviews] Free radicals, antioxidants and cancer chemotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[Reviews] Free radicals, antioxidants and cancer chemotherapy","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["1539","3482"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-01-31"},"publish_date":"2011-01-31","publish_status":"0","recid":"10516","relation_version_is_last":true,"title":["[Reviews] Free radicals, antioxidants and cancer chemotherapy"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T18:49:04.799987+00:00"}