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Human T-cell leukemia virus type 1 (HTLV-1) infection and the chemokine system
https://kindai.repo.nii.ac.jp/records/10500
https://kindai.repo.nii.ac.jp/records/105007c11540a-bc09-4ffc-9546-0d27cd90b327
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-20081200-0023.pdf (1.8 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2010-07-06 | |||||||||
| タイトル | ||||||||||
| タイトル | Human T-cell leukemia virus type 1 (HTLV-1) infection and the chemokine system | |||||||||
| 言語 | en | |||||||||
| 著者 |
Hieshima, Kunio
× Hieshima, Kunio
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| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | HTLV-1, ATL, Tax, chemokine, chemokine receptor | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 著者所属(翻訳) | ||||||||||
| 値 | Department of Microbiology, Kinki University School of Medicine | |||||||||
| 版 | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 33, 号 1/2, p. 23-34, 発行日 2008-12-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 03866092 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Human T-cell leukemia virus type 1 (HTLV-1) is a human retrovirus that causes adult T-cell leukemia (ATL). ATL is a malignancy of mature CD4^＋ T cells with poor prognosis. HTLV-1 genome encodes a potent transcriptional regulator, namely, Tax, which plays a critical role in CD4^＋ T-cell transformation. However, Tax exerts its action only in the initial phase of ATL tumorigenesis because it is usually not detectable in ATL cells. A prominent role of the chemokine system is the regulation of leukocyte trafficking, including CD4^＋ T-cell. Here, we briefly summarize HTLV -1 infection and ATL and discuss the recent findings of the involvement of the chemokine system in HTLV-1 infection and ATL tumorigenesis. | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
