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Biological Consequences of Fumonisins
https://kindai.repo.nii.ac.jp/records/9868
https://kindai.repo.nii.ac.jp/records/9868f11bddbb-684b-4f99-a8b6-1ad986aad526
| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-11-22 | |||||
| タイトル | ||||||
| タイトル | Biological Consequences of Fumonisins | |||||
| 著者 |
Thomas, Shier W.
× Thomas, Shier W.× Resch, Petra× Badria, Farid× Abbas, Hamed K. |
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| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 所属 | ||||||
| 値 | Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota | |||||
| 著者 所属 | ||||||
| 値 | Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota:Research Center for Food and Milk, Technical University of Munich | |||||
| 著者 所属 | ||||||
| 値 | Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota:Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University | |||||
| 著者 所属 | ||||||
| 値 | Southern Weed Science Research Unit/Crop Genetics and Production Research Unit, US Dept. of Agriculture, Agricultural Research Service | |||||
| 出版者 名前 | ||||||
| 出版者 | 近畿大学農学総合研究所 | |||||
| 書誌情報 |
近畿大学農学総合研究所報告 en : Bulletin of the Institute for Comprehensive Agricultural Sciences, Kinki University 号 8, p. 67-74, 発行日 2000-03-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09193022 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | [Synopsis] Fumonisins are a series of mycotoxins produced primarily by Fusarium moniliforme, a ubiquitous contaminant of corn (maize), and F. proliferatum, a common contaminant of sorghum and rice afflicted with Fusarium sheath rot disease. Fumonisins are presumed to be tumor promoters because of the bioassay used to guide their initial isolation. Fumonisin B_1 (FB_1) has been shown to cause leukoencephalomalacia in horses, pulmonary edema in swine and cancer in rats and mice. Fumonisins are structural analogs of AAL-toxins produced by Altemaria alternata, and the putative second messenger sphingosine. Fumonisins became a food safety concern when they were demonstrated to be common contaminants of corn-derived foods and feeds. In vitro studies of mammalian cytotoxicity and phytotoxicity showed that many changes can be made in the FB_1 structure without loss of biological activity. Studies on the fate of FB_1 during food processing were initiated because of concern that FB_1 apparently destroyed during cooking of corn-derived foods may be converted to other toxic forms. During cooking radiolabeled FB_1 became covalently bound to corn proteins through side chains in a manner which may allow its release in a toxic form on digestion. Further research is needed to determine the threat to food safety posed by protein-bound mycotoxins. | |||||
