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核骨格タンパク質の機能と胚発生における役割
https://doi.org/10.15100/00023805
https://doi.org/10.15100/0002380507b65fd4-e9bf-45a2-9ea3-04c189e860ef
名前 / ファイル | ライセンス | アクション |
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AA11153712-20230331-0033.pdf (2.0 MB)
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Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2023-03-28 | |||||
タイトル | ||||||
タイトル | 核骨格タンパク質の機能と胚発生における役割 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Cellular functions of nucleoskeleton proteins and their roles in embryonic development | |||||
著者 |
坂上, 凜
× 坂上, 凜× 宮川, 靖基× 宮本, 圭 |
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言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | 核骨格タンパク質, 発生, ラミン, 核アクチン Nucleoskeleton protein, Development, Lamin, Nuclear actin |
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資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15100/00023805 | |||||
ID登録タイプ | JaLC | |||||
著者(英) | ||||||
en | ||||||
Sakanoue, Rin | ||||||
著者(英) | ||||||
en | ||||||
Miyagawa, Yasuki | ||||||
著者(英) | ||||||
en | ||||||
Miyamoto, Kei | ||||||
著者 所属 | ||||||
近畿大学大学院生物理工学研究科 生物工学専攻 | ||||||
著者 所属 | ||||||
近畿大学生物理工学部 遺伝子工学科 | ||||||
著者 所属 | ||||||
近畿大学大学院生物理工学研究科 生物工学専攻: 近畿大学生物理工学部 遺伝子工学科 | ||||||
著者所属(翻訳) | ||||||
Major in Biotechnological Science, Graduate School of Biology-Oriented Science and Technology, Kindai University | ||||||
著者所属(翻訳) | ||||||
Department of Genetic Engineering, Faculty of Biology Oriented Science and Technology, Kindai University | ||||||
著者所属(翻訳) | ||||||
Major in Biotechnological Science, Graduate School of Biology-Oriented Science and Technology, Kindai University: Department of Genetic Engineering, Faculty of Biology Oriented Science and Technology, Kindai University | ||||||
版 | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
出版者 名前 | ||||||
出版者 | 近畿大学生物理工学部 | |||||
書誌情報 |
近畿大学生物理工学部紀要 en : Memoirs of the Faculty of Biology-Oriented Science and Technology of Kindai University 号 50, p. 33-43, 発行日 2023-03-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13427202 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | [要旨]脊椎動物の核は、脂質二重層である核膜によって細胞質と隔てられている。核内では、遺伝情報であるDNAがヒストンタンパク質に巻き付くことで凝縮し、核膜に内包されて存在している。また、間期核におけるクロマチン高次構造の解析により、転写活性化状態にあるAコンパートメントや不活性状態のBコンパートメントのような核内の三次元構造が転写活性と相関していることが示された。これらのクロマチン高次構造の安定化には適切な核構造の確立や維持が必要であり、核骨格タンパク質が重要な役割を果たしている。核骨格タンパク質にはラミンやアクチンが含まれ、これらのタンパク質は核の構造維持だけにはとどまらず、転写状態やクロマチン構造の確立にも関与していることが知られている。ラミンはLamina-associated domains (LAD)における転写を制御する他、老化や様々な疾患に関与していることが明らかになってきている。また、核内に存在するアクチンタンパク質(核内アクチン)は多様な生物においてその存在が確認され、種々の役割を果たしていることが示されてきている。そこで、本総説ではこれらの二つの核骨格タンパク質に焦点を当て、核内におけるラミンおよび、アクチンの細胞生物学的機能について最新の知見を紹介する。また、核骨格タンパク質の動物胚発生への関与についても紹介し、今後の研究の方向性についても論ずる。 [英文抄録] The vertebrate nucleus is physically separated from the cytoplasm by the lipid bilayer, nuclear envelope. In the nucleus, DNA is condensed by histone proteins, forming chromatin, and is encased by the nuclear envelope. Milestone studies on chromatin conformation in the interphase nucleus have revealed that, transcriptionally active and inactive genes are enriched in the so-called A and B compartment, respectively, suggesting that 3D chromatin organization plays an important role in transcriptional regulation. In order to establish proper chromatin organization, the nuclear structure itself can serve as a key factor, and it is maintained by nucleoskeleton proteins. Nucleoskeleton proteins include lamins and nuclear actin, which are involved in not only nuclear architecture maintenance but also transcription and chromatin organization. Recent studies demonstrate that lamins are involved in the regulation of transcription especially from lamina associated domains (LAD) and are important for preventing cellular senescence and various diseases. Furthermore, nuclear actin is involved in a variety of biological processes across species. Here, we focus on these two nucleoskeleton proteins, namely lamins and nuclear actin. We introduce the latest findings about nuclear roles of lamins and actin in the context of cellular biology. Moreover, we introduce developmental roles of nucleoskeleton proteins in diverse animal species. Finally, we discuss the future research direction regarding the emerging research topic on nucleoskeleton proteins and embryonic development. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Review | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |