| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2021-05-20 |
| タイトル |
|
|
タイトル |
<Originals> Comprehensive analysis of cytokines in bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis : a cross-sectional study |
|
言語 |
en |
| 著者 |
Matsuhira, Takashi
Nishiyama, Osamu
Chiba, Yasutaka
Sano, Hiroyuki
Iwanaga, Takashi
Tohda, Yuji
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
bronchoalveolar lavage, IPF, TNF-α, MMP, pulmonary function |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.15100/00021779 |
|
ID登録タイプ |
JaLC |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine: Pharmaceutical Research Center, Meiji Seika Pharma Co., Ltd |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Division of Biostatistics, Clinical Research Center, Kindai University |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine |
| 版 |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| 出版者 名前 |
|
|
出版者 |
Kindai University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY
巻 46,
号 1,
p. 1-7,
発行日 2021-06
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, with a poor prognosis. The underlying molecular pathogenic mechanisms are not fully understood. The aim of this study was to investigate the relationship between concentrations of various proteins in bronchoalveolar lavage (BAL) fluid (BALF) and clinical parameters in consecutive patients with IPF, including those with preserved lung function. Concentrations of various proteins (SDF-1α , IP-10, IL-1β , IL-4, IL-6, IL-8, IL-13, IFN-r, TNF-α, EGF, FGF, PDGF, Galectin-3, MMP-1, MMP-7, MMP-8, and TGF-β ) in the BALF collected from ten patients with IPF were determined. As a result, BALF concentrations of TNF-α, MMP-1, -7, and -8 showed trends toward positive correlations with forced vital capacity (FVC) % predicted (r=0.605, 0.527, 0.406, and 0.624, respectively), although statistical significance was not reached. These results suggested that these molecules are elevated more in the BALF of patients with earlier IPF. These proteins may be involved in the initial phase of pathogenesis and may possibly be new therapeutic targets in early IPF. |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20210600-0001 (246.3 kB)
