| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2019-06-17 |
| タイトル |
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|
タイトル |
<Original> Presurgical targeted molecular therapy for advanced renal cell carcinoma: Long-term clinical outcomes in a Japanese population |
|
言語 |
en |
| 著者 |
Ohzeki, Takayuki
Hashimoto, Mamoru
Shimizu, Nobutaka
Minami, Takafumi
Nozawa, Masahiro
Nose, Kazuhiro
Yoshimura, Kazuhiro
Uemura, Hirotsugu
|
| 言語 |
|
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言語 |
eng |
| キーワード |
|
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主題 |
Presurgical therapy, Renal cell carcinoma, Targeted molecules |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 所属 |
|
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Department of Urology, Kindai University Faculty of Medicine |
| 著者 所属 |
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Department of Urology, Kindai University Faculty of Medicine |
| 著者 所属 |
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Department of Urology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
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Department of Urology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
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Department of Urology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
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Department of Urology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
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Department of Urology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
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Department of Urology, Kindai University Faculty of Medicine |
| 版 |
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出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| 出版者 名前 |
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出版者 |
Kindai University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY
巻 43,
号 2,
p. 69-74,
発行日 2018-12
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
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内容記述 |
[Abstract] Purpose: This study is to investigate the efficacy and safety of presurgical targeted molecular therapy with tyrosine kinase inhibitors (TKIs) and mammalian targets of rapamycin inhibitors (mTORIs) for advanced renal cell carcinoma in a Japanese population. Methods: We retrospectively identified patients with renal cell carcinoma treated with targeted molecules before tumor resection. Results: Between July 2008 and February 2014, 11 patients were treated with targeted molecular therapy and subsequently underwent resection. Operations were performed by open laparotomy in all cases for locally advanced and metastatic disease, with the exception of one patient who had an inoperable tumor. The average reduction rates of primary tumor and metastases were −14.9% (range, −47～ +18%) and −35.7% (range, −100～+40%), respectively. Cancer-related deaths tended to occur in patients who had weak reduction of primary tumor despite therapy. Two patients had minor perioperative complications, including wound healing delay and infection. Pathological analysis revealed clear cells in all cases. Conclusions: Surgical resection of renal cell carcinoma after targeted therapy was feasible with low morbidity in most patients. Presurgical therapy might help identify patients with renal cell carcinoma who have a poor prognosis and might not achieve survival benefit from cytoreductive surgery. |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20181200-0069.pdf (333.7 kB)
