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Association of lower serum sclerostin levels with elevated risk for increased arterial stiffness: The JPOS Cohort Study
https://kindai.repo.nii.ac.jp/records/2001758
https://kindai.repo.nii.ac.jp/records/20017584e9918ac-8306-4953-9460-965121d7086a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Supplemental Table 20240902.pdf (323 KB)
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| アイテムタイプ | データセット / detaset(1) | |||||||||
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| 公開日 | 2024-09-02 | |||||||||
| タイトル | ||||||||||
| タイトル | Association of lower serum sclerostin levels with elevated risk for increased arterial stiffness: The JPOS Cohort Study | |||||||||
| 言語 | en | |||||||||
| その他のタイトル | ||||||||||
| その他のタイトル | 血清スクレロスチン低濃度と動脈硬化進展との関連：JPOSコホート研究 | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
伊木, 雅之
× 伊木, 雅之
e-Rad
50184388
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| キーワード | ||||||||||
| 主題 | arterial stiffness, bone-vessel cross-talk, cohort study, Japanese women, osteoporosis, sclerostin | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Objectives: Studies on the relationship between serum sclerostin, a Wnt/β-catenin pathway inhibitor, and atherosclerosis have yielded inconsistent results. We aim to longitudinally investigate the relationship between serum sclerostin levels and the risk of increased arterial stiffness in Japanese communitydwelling women. Methods: Of 1044 women aged ≥50 years whose brachial-ankle pulse wave velocity (baPWV) value was available in a baseline survey in 2011-2012, we excluded 374 whose baPWVs were ≥1800 cm/s, set as the cutoff for increased arterial stiffness, and eight with missing data. Of the remaining 662 women, we included in the analysis 556 followed in the 4- to 5-year follow-up study. The coefficient of variation of the sclerostin measurement was 3.45%. We obtained odds ratios (ORs) for sclerostin at baseline categorized by tertiles, with the high tertile as reference for increased arterial stiffness. Results: Ninety-four women showed increased arterial stiffness during a mean follow-up of 4.0 years. The increased arterial stiffness rates in the low, medium, and high tertiles were 22.2%, 16.1%, and 12.4%, respectively (trend test p = 0.013). The ORs for the medium and low tertiles for increased arterial stiffness were 1.58 (p = 0.205) and 2.16 (p = 0.027), respectively, after adjusting for age and baseline baPWV. After further adjustment for baseline BMI, hypertension, hyperlipidemia, diabetes mellitus, eGFR, and BMC at whole body, the ORs for the medium and low tertiles were 1.65 (p = 0.181) and 2.50 (p = 0.014), respectively. Conclusion: Lower serum sclerostin levels were associated with elevated risks for increased arterial stiffness in Japanese community-dwelling women. |
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| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_ddb1 | |||||||||
| 資源タイプ | dataset | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
