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<Original> Atorvastatin promoted in vitro angiogenesis by reduction of geranylgeranyl pyrophosphate in a dose-dependent manner and protected against rho kinase-mediated endothelial cell damage caused by thromboxane A2
https://kindai.repo.nii.ac.jp/records/19497
https://kindai.repo.nii.ac.jp/records/194974ac30f6e-809b-42d7-b11b-ec26a4516154
名前 / ファイル | ライセンス | アクション |
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AA0050842X-20180600-0035.pdf (713.7 kB)
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Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-07-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | <Original> Atorvastatin promoted in vitro angiogenesis by reduction of geranylgeranyl pyrophosphate in a dose-dependent manner and protected against rho kinase-mediated endothelial cell damage caused by thromboxane A2 | |||||
著者 |
Yokota, Ryoji
× Yokota, Ryoji× Nishi, Yuko× Sugitani, Yuuki× Tamada, Hiroyuki× Ohi, Yohei× Ishikawa, Chisato× Ohe, Kentarou× Uemori, Noritsugu× Mitsuoka, Hirokazu× Togi, Kiyonori× Shirotani, Manabu |
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言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Angiogenesis, Endothelial cells, Statin, Geranylgeranyl pyrophosphate, Rho kinase, Thromboxane A2, Caspase-3 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
著者 所属 | ||||||
Cardiovascular Center, Nara Hospital, Kindai University Faculty of Medicine | ||||||
版 | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
出版者 名前 | ||||||
出版者 | Kindai University Medical Association | |||||
書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY 巻 43, 号 1, p. 35-42, 発行日 2018-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03866092 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | [Abstract] Background: Atorvastatin can inactivate Rho/Rho kinase via a reduction in the synthesis of geranylgeranyl pyrophosphate (GGPP).Thromboxane A2 (TxA2) causes endothelial cell (EC) apoptosis via Rho/Rho kinase activation.We tested the hypothesis that atorvastatin protects against the Rho kinase-mediated anti-angiogenic effect of TxA2. Methods: We used human coronary artery ECs to form tubular structures on plates coated with a basement membrane matrix gel. The number of tubular structure was counted under a microscope. The caspase-3 activity was used as a determinant of apoptosis.Results: Atorvastatin significantly increased the number of tubes in a dose-dependent manner, and this effect was blocked by mevalonate or geranylgeranyl pyrophosphate (GGPP). Similar to atorvastatin, a potent selective inhibitor of geranylgeranyl transferase type I enhanced tubular formation. A TxA2 mimetic (IBOP) inhibited formation of EC tubular structures. The inhibitory effect was completely blocked by a TxA2 antagonist (SQ29548), a Rho kinase inhibitor (Y27632), and by atorvastatin. The IBOP-induced increase in caspase-3 activity was attenuated by atorvastatin. Conclusions: Atorvastatin promoted in vitro angiogenesis of ECs in a dose-dependent manner and reversed the TxA2 receptor-mediated antiangiogenic effect. We suggest that reduction of GGPP and inactivation of Rho kinase plays an important role in the proangiogenic effect of atorvastatin. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |