| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2010-07-22 |
| タイトル |
|
|
タイトル |
Experimental study on preventive effects of statin and ARB for metabolic syndrome : using a new animal model, obese stroke-prone spontaneous hypertensive rats |
|
言語 |
en |
| 著者 |
Masuno, Koichi
Takemori, Kumiko
Inoue, Takao
Yamamoto, Kazuo
Ito, Hiroyuki
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
SHRSP/IDmcr-fa/fa rats, HMG-CoA reductase inhibitor, angiotensin II receptor blocker, adiponectin |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者所属(翻訳) |
|
|
値 |
Department of Pathology, Kinki University, Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Department of Pathology, Kinki University, Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Department of Pathology, Kinki University, Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Department of Pathology, Kinki University, Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Department of Pathology, Kinki University, Faculty of Medicine |
| 版 |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| 出版者 名前 |
|
|
出版者 |
The Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 35,
号 1,
p. 33-40,
発行日 2010-06-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
SHRSP/IDmcr-fa/fa (SHRSP/fatty) rats are a new animal model that have the potential to develop severe hypertension, obesity, hyperlipidemia, and hyperglycemia, followed by arteriopathy and glomerulopathy in the kidneys. Thus, SHRSP/fatty rats seem to be the most severe animal model of human metabolic syndrome. Using this unique animal model, we investigated how HMG-CoA reductase inhibitor (statin), a well-known drug for hypercholesterolemia, and angiotensin II receptor blocker (ARB), a widely-used anti-hypertensive drug, affected the pathophysiology related to metabolic syndrome. The statin increased the mRNA expression of adiponectin and leptin, decreased the expression of TNF-alpha gene, and increased the secretion of high molecular weight (HMW) adiponectin, without a lipid-lowering effect. ARB increased both total adiponectin and HMW adiponectin, independent of blood pressure lowering. Histologically, the incidence of renal lesions, such as angionecrosis and glomerulosclerosis, was decreased in both treated groups. Except for well-known pharmacological effects of these drugs, the additional medicinal benefit of the statin depended on its anti-inflammatory effect, and that of ARB probably depended on its direct effect on adipocytes. It was considered that the increase of HMW adiponectin was enhanced by both pathways, and this may be a common factor of the protective effects of both drugs on pathophysiological damages in SHRSP/fatty rats. |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20100600-0033.pdf (2.1 MB)
