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Biomarker of exposure to fumonisins and its use to evaluate the in vivo effectiveness of methods for commodities detoxification.
https://kindai.repo.nii.ac.jp/records/9879
https://kindai.repo.nii.ac.jp/records/9879302397af-d3b9-470d-aed9-78a1ac5cde16
| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||
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| 公開日 | 2011-11-28 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Biomarker of exposure to fumonisins and its use to evaluate the in vivo effectiveness of methods for commodities detoxification. | |||||||||||||
| 著者 |
Solfrizzo, Michele
× Solfrizzo, Michele
× Avantigiatto, Giusepina
× Girolamo, Annalisa De
× Visconti, Angelo
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| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | metadata only access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||||
| 著者 所属 | ||||||||||||||
| 値 | Istituto Tossine e Micotossine da Parassiti Vegetali. CNR | |||||||||||||
| 著者 所属 | ||||||||||||||
| 値 | Istituto Tossine e Micotossine da Parassiti Vegetali. CNR | |||||||||||||
| 著者 所属 | ||||||||||||||
| 値 | Istituto Tossine e Micotossine da Parassiti Vegetali. CNR | |||||||||||||
| 出版者 名前 | ||||||||||||||
| 出版者 | 近畿大学農学総合研究所 | |||||||||||||
| 書誌情報 |
近畿大学農学総合研究所報告 en : Bulletin of the Institute for Comprehensive Agricultural Sciences, Kinki University 号 7, p. 17-25, 発行日 1999-03-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 09193022 | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | [Synopsis] The increase of sphinganine/sphingosine (SA/SO) ratio in biological fluids and tissues is currently adopted as biomarker to display early toxicity and exposure to fumonisins, mycotoxins largely occurring in maize worldwide and produced by Fusarium moniliforme and F. proliferatum. Results of the recent work carried out at our Institute with this biomarker is reviewed herein. We have developed a rapid, precise and accurate method for the determinatin of SA and SO in human and animal urine and tissue samples suitable for epidemiological studies and animal experiments. A study carried out on rats fed with diets containing increasing doses of fumonisins, allowed to establish the threshold level of toxins required to trigger the biomarker response in urine and showed a good correlation between the ingestion of fumonisins through the diet and the urinary SA/SO value. The biomarker has been used to evaluate the in vivo effectiveness of cholestyramine and activated carbon in sequestering fumonisins. The addition of cholestyramine to fumonisins contaminated diets was shown to protect rats from the toxic effect of fumonisins. The protective effect of activated carbon was lower than that of cholestyramine. | |||||||||||||
