{"created":"2023-06-20T16:39:43.525808+00:00","id":9861,"links":{},"metadata":{"_buckets":{"deposit":"8fac875a-176b-4a0c-8ca9-686329331bef"},"_deposit":{"created_by":3,"id":"9861","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"9861"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00009861","sets":["14:923:2473:2477","21:3039:3413:3420"]},"author_link":["17882","17881"],"item_2_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of administration of rice treated with artificial digestive enzymes on intestinal bacterial flora of rats"}]},"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"109","bibliographicPageStart":"99","bibliographic_titles":[{"bibliographic_title":"近畿大学農学総合研究所報告"},{"bibliographic_title":"Bulletin of the Institute for Comprehensive Agricultural Sciences, Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Synopsis] To prevent overeating and reduce the burden on digestive organs by increasinn the rate of digestion and absorption, we produced rice treated with artificial digestive enzymes (pancreatin +diastase = ADE)and evaluated the effects of ADE rice administration on the body, especially on intestinal bacterial flora of rats. The following results and suggestion were obtained.       1. ADE rice showed decreased protein and fat conteints and an increased suger content compared with non-treated rice.    2. The body weight and the epididymal fat weight increased.   3. The digestive tract was slightly shortened, although the length of the large intestine decreased.   4. The bile acid content in stools was similar between rats administered with ADE rice and untreated rice.   5. Bacteroides and Eubacterium in the cecum decreased.    6. Total serum cholesterol slitly increased while blood sugar and serum neutral fat increased.     7. Along with weak acidification, an increase in Bifidobacterium and a decrease in the bile acid pool in the intestine were observed, suggesting a posible of carcinogenesis and the development of living habit-associated diseases due to increased useful metabolites.   8. No preventive effects on obesity were observed. Digestive enzyme in ADE rice promoted hydrolysis of starch, and glucose was used for the synthesis of neutral fat in fat cells, increasing body weight and fat weight. However, these increases may not be due to an increase in fat tissue since bile acid in stools decreased. Shortening of the digestive tract made digestion and absorption in the body efficient, shortened the time of stagnation of large intestinal contents, and shortened the time of uptake of carcinogenic substances and intestinal mucosa. These may be useful for decreasing the carcinogenesis rate and preventing living habits-associated diseases. Intracecal acidification, inhibition of bile acid production, and a decrease in amino acid due to a decrease in proteins are most likely reduce the production of ammonia or phenols, inhibiting production of toxic substances. On the other hand, a decrease in the bile acid pool due to a decrease in fat appear to improve intestanal bacterial flora which may exert anti-cancer effects. Ade rice, which reduces the burden of the digestive organs, making digestion • absorption efficient, may be effective as a food material for treatment of patients with digestive diseases oraged people.         [要約] 経口摂取された食餌の一部は腸内細菌によって代謝され、宿主に有用または有害に働く物質が生成され、健康増進や阻害因になる可能性が指摘されていることから、生活習慣病対策治療食品として考案・開発した人工消化酵素処理(ADE)米の生体、特に腸内細菌相に及ぼす影響をラットを用いて調べた。パンクレアチンは有用腸内細菌Bifidobacteriumの増殖を促進することから、ADE米は生活習慣病治療食品として優れた機能を発揮することが示唆された。ADE米は、デンプンが分解され速やかに消化吸収され、急速な血糖上昇をもたらし、膵臓からのインシュリンが分泌を促進して、糖の脂肪細胞への取り込みと中性脂肪の合成に使われると考えられた。ただ、餌料摂取量が無変化にも拘わらず体重と脂肪重量は増加したが、糞便中の胆汁酸は低下したことから、脂肪に由来した脂肪組織の増量でないと判断された。ADE米投与ラットの消化管は短化したが、これは摂取により体内での消化吸収が効率的となった結果と考えられ、大腸内容物の滞腸時間が短縮されることから、発癌物質等と腸粘膜の接触時間も短縮され、発癌率や生活習慣病の予防に有効となることが示唆された。ADE米群の盲腸内容物のpHは、他群に比して酸性側となったが、これも腸内腐敗菌の増殖を抑制し、発癌作用を有する二次胆汁酸生成の抑制に連なることを推察させる。ADE米摂取により、Proteusが検出されたが極少数に限られた。腸内腐敗菌や腸管炎症の抑制及び血流や消化吸収の生理的機能の改善に有効なBifidobacteriumは増加し、好ましい菌相を示した。これらの現象は、ADE処理がデンプンをオリゴ糖に変換させたことによるものと考えられた。ADE米は、低タンパク質化によるアミノ酸の減少に伴い、アンモニアやフエノール等の有害物質の発生を抑制し、低脂肪化による胆汁酸プールの減少によって、腸内細菌相を改善させて抗癌作用を高めることが示唆された。一方、米粒中の還元糖の増加により糖質が速やかにトリアシルグリセロールとして脂肪組織に蓄積されることが認められた。ADE米は、消化器官の負担軽減により消化吸収が効率的となり、消化器疾患者や高齢者等の治療食材として有効であり、腸内の弱酸性化やBifidobacteriumの増加及び胆汁酸プールの減少など生活習慣病の発症抑制効果があることが示唆された。なお、肥満効果は認められなかった。","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学農学総合研究所"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09193022","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Tajiri, Takashi"},{"subitem_text_language":"en","subitem_text_value":"Higashino, Hideaki"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学総合研究所"},{"subitem_text_value":"近畿大学医学部"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"The Institute for Comprehensive Agricultural Sciences, Kinki University"},{"subitem_text_value":"Kinki University School of Medicine"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田尻,  尚士"},{"creatorName":"タジリ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東野,  英明"},{"creatorName":"ヒガシノ, ヒデアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AN10410378-20000315-0099.pdf","filesize":[{"value":"421.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10410378-20000315-0099.pdf","url":"https://kindai.repo.nii.ac.jp/record/9861/files/AN10410378-20000315-0099.pdf"},"version_id":"dfe19722-3a76-412f-8efb-4ced8f4385fd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"人工消化酵素処理米投与がラットの腸内細菌相におよぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"人工消化酵素処理米投与がラットの腸内細菌相におよぼす影響"}]},"item_type_id":"2","owner":"3","path":["2477","3420"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-11-22"},"publish_date":"2011-11-22","publish_status":"0","recid":"9861","relation_version_is_last":true,"title":["人工消化酵素処理米投与がラットの腸内細菌相におよぼす影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:52:18.406267+00:00"}