@article{oai:kindai.repo.nii.ac.jp:00009581, author = {佐野, 雅子 and 中川, 佳奈 and 山口, 仁宏 and 中島, 暉躬 and 若宮, 建昭}, issue = {42}, journal = {近畿大学理工学部研究報告, Journal of the Faculty of Science and Engineering, Kinki University}, month = {Sep}, note = {The neurotoxic acylpolyamine NPTX-594 (1) was isolated from the venom of a Madagascar Joro spider. The toxin is comprised of four constituents, i.e., 2,4-dihydroxyphenylacetic acid (Dhpa), asparagine (Asn), 4,8-diaza-1,12-dodecanediamine (Dada) and lysine (Lys). Although spider toxins are known to be strong and specific blocker against the glutamate receptors (GluRs), the interaction between the toxins and the receptors has not been clarified yet. In order to confirm visually the complex formation between spider toxins and GluRs, the syntheses of several fluorescent labeled analogs of NPTX-594 were carried out. Furthermore, the biological activities of synthetic compounds are also described., 第42回ペプチド討論会(2005年10月, 大阪)にて一部発表 本文データの一部はCiNiiから複製したものである。, application/pdf}, pages = {23--28}, title = {クモ毒NPTX-594の蛍光標識類縁体の合成と生物活性に関する研究}, year = {2006}, yomi = {サノ, マサコ and ナカガワ, カナ and ヤマグチ, ヨシヒロ and ナカジマ, テルミ and ワカミヤ, タテアキ} }