{"created":"2023-06-20T16:37:36.577047+00:00","id":7382,"links":{},"metadata":{"_buckets":{"deposit":"59d7583e-3127-499b-8881-72092a52da4e"},"_deposit":{"created_by":3,"id":"7382","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"7382"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00007382","sets":["14:923:1711:1712","21:3039:3241:3289"]},"author_link":["12672","12675","12674","12673","12670","12671","12676"],"item_2_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"<Original Papers>Effects of orally administered synthetic nobiletin on rat dermis"}]},"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"48","bibliographicPageEnd":"17","bibliographicPageStart":"13","bibliographic_titles":[{"bibliographic_title":"近畿大学工学部研究報告"},{"bibliographic_title":"Research reports of the Faculty of Engineering, Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Abstract] Shiikuwasha (Citrus depressa Hayata), a typical Japanese citrus fruit, recently has been expected to make the healthy skin. Nobiletin (5, 6, 7, 8, 3', 4'-hexamethoxy flavone), a citrus polymethoxy flavonoid, is one of the compounds of Shiikuwasha. Nobiletin has been reported in in vitro studies that it possesses various bioactive effects, such as anti-inflammatory activities, however, few in vivo studies have been done. In this study, we examined the effects of nobiletin involved in the impact on the collagenolysis. We revealed that nobiletin increases mRNA expressions of anti-oxidant enzymes. Furthermore, nobiletin suppresses mRNA expressions of matrix metalloproteinases (MMPs) and increases mRNA expressions of peroxisome proliferator activated receptors (PPARs). These results suggest that anti-oxidative action and suppression of the collagenolysis in the dermis may be enhanced through the oral administration of nobiletin.","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学工学部研究報告"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386491X","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KURAMOTO, Junko"},{"subitem_text_language":"en","subitem_text_value":"INOUE, Takayuki"},{"subitem_text_language":"en","subitem_text_value":"MOTOYA, Tomoyuki"},{"subitem_text_language":"en","subitem_text_value":"OGAWA, Noriko"},{"subitem_text_language":"en","subitem_text_value":"FURUYA, Motohide"},{"subitem_text_language":"en","subitem_text_value":"NOMURA, Masato"},{"subitem_text_language":"en","subitem_text_value":"OTANI, Hiroki"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"島根大学医学部解剖学講座発生生物学"},{"subitem_text_value":"島根大学医学部解剖学講座発生生物学"},{"subitem_text_value":"島根大学医学部解剖学講座発生生物学"},{"subitem_text_value":"島根大学医学部解剖学講座発生生物学"},{"subitem_text_value":"島根大学医学部解剖学講座発生生物学"},{"subitem_text_value":"近畿大学工学部化学生命工学科"},{"subitem_text_value":"島根大学医学部解剖学講座発生生物学"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Developmental Biology, Faculty of Medicine, Shimane University"},{"subitem_text_value":"Department of Developmental Biology, Faculty of Medicine, Shimane University"},{"subitem_text_value":"Department of Developmental Biology, Faculty of Medicine, Shimane University"},{"subitem_text_value":"Department of Developmental Biology, Faculty of Medicine, Shimane University"},{"subitem_text_value":"Department of Developmental Biology, Faculty of Medicine, Shimane University"},{"subitem_text_value":"Department of Biotechnology and Chemistry, Faculty of Engineering, Kinki University"},{"subitem_text_value":"Department of Developmental Biology, Faculty of Medicine, Shimane University"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"倉本,  純子"},{"creatorName":"クラモト, ジュンコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井上,  隆之"},{"creatorName":"イノウエ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"元矢,  知志"},{"creatorName":"モトヤ, トモユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川,  典子"},{"creatorName":"オガワ, ノリコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"古屋,  智英"},{"creatorName":"フルヤ, モトヒデ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野村,  正人"},{"creatorName":"ノムラ, マサト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大谷,  浩"},{"creatorName":"オオタニ, ヒロキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AN00063799-20141220-0013.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00063799-20141220-0013.pdf","url":"https://kindai.repo.nii.ac.jp/record/7382/files/AN00063799-20141220-0013.pdf"},"version_id":"ccb85b16-e04c-4dc3-b0fc-bd2e70469c9e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Citrus depressa Hayata","subitem_subject_scheme":"Other"},{"subitem_subject":"Nobiletin","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-oxidant","subitem_subject_scheme":"Other"},{"subitem_subject":"Collagen","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<研究論文>合成ノビレチンの経口投与によるラット真皮への影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<研究論文>合成ノビレチンの経口投与によるラット真皮への影響"}]},"item_type_id":"2","owner":"3","path":["1712","3289"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-02-02"},"publish_date":"2015-02-02","publish_status":"0","recid":"7382","relation_version_is_last":true,"title":["<研究論文>合成ノビレチンの経口投与によるラット真皮への影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T00:16:57.394874+00:00"}