@article{oai:kindai.repo.nii.ac.jp:00007382,
 author = {倉本,  純子 and 井上,  隆之 and 元矢,  知志 and 小川,  典子 and 古屋,  智英 and 野村,  正人 and 大谷,  浩},
 issue = {48},
 journal = {近畿大学工学部研究報告, Research reports of the Faculty of Engineering, Kinki University},
 month = {Dec},
 note = {[Abstract] Shiikuwasha (Citrus depressa Hayata), a typical Japanese citrus fruit, recently has been expected to make the healthy skin. Nobiletin (5, 6, 7, 8, 3', 4'-hexamethoxy flavone), a citrus polymethoxy flavonoid, is one of the compounds of Shiikuwasha. Nobiletin has been reported in in vitro studies that it possesses various bioactive effects, such as anti-inflammatory activities, however, few in vivo studies have been done. In this study, we examined the effects of nobiletin involved in the impact on the collagenolysis. We revealed that nobiletin increases mRNA expressions of anti-oxidant enzymes. Furthermore, nobiletin suppresses mRNA expressions of matrix metalloproteinases (MMPs) and increases mRNA expressions of peroxisome proliferator activated receptors (PPARs). These results suggest that anti-oxidative action and suppression of the collagenolysis in the dermis may be enhanced through the oral administration of nobiletin., application/pdf},
 pages = {13--17},
 title = {<研究論文>合成ノビレチンの経口投与によるラット真皮への影響},
 year = {2014},
 yomi = {クラモト, ジュンコ and イノウエ, タカユキ and モトヤ, トモユキ and オガワ, ノリコ and フルヤ, モトヒデ and ノムラ, マサト and オオタニ, ヒロキ}
}