@article{oai:kindai.repo.nii.ac.jp:00007355, author = {Wu, Shuhsien and Tachibana, Shinya and Tanimoto, Shinichi and Inoue, Toshio and Murai, Yoshihira and Watanabe, Yoshiyuki and Okada, Yoshiharu and Nomura, Masato}, journal = {近畿大学工学部研究報告, Research reports of the Faculty of Engineering, Kinki University}, month = {Dec}, note = {[SUMMARY] For ensuring useful materials including pharmaceutical compounds, it is important to extract and separate the underlying leading compounds from natural products such as plants, and to characterize their structure and pharmacological activity. Kaempferol (1), quercetin (2), quercitrin (3), rutin (4), hesperetin (5), and hesperidin (6) used in this study were flavonoids having a phenylchroman skeleton as the basic structure. Antioxidant ability, skin-whitening effect, and histamine-release suppressing effect were examined as their new physiological activities in this study. As a result, in DPPH radical scavenging effect test, which evaluates activity of antioxidant ability, high scavenging effect (90-96%) was observed in (1), (2), and (4). In skin-whitening effect test, it was clarified that (1) and (2) exert higher tyrosinase inhibition activity (42-60) than that of commercially available arbutin (7.3). In toxicity test using human alveolar epithelial cells (in vitro), meanwhile, no difference from control was observe in (3), (4), (5), and (6) at 100 μM concentration, and it was reasoned that there are no considerable toxicity., application/pdf}, pages = {7--13}, title = {〈Original Papers〉Physiological Activities of Several Different Types of Flavonoids}, volume = {46}, year = {2012}, yomi = {タチバナ, シンヤ and タニモト, シンイチ and イノウエ, トシオ and ムライ, ヨシヒラ and ワタナベ, ヨシユキ and オカダ, ヨシハル and ノムラ, マサト} }