{"created":"2023-06-20T16:36:16.805352+00:00","id":5775,"links":{},"metadata":{"_buckets":{"deposit":"3a4d8d9b-9454-4d24-ba7d-7e7b9776a610"},"_deposit":{"created_by":3,"id":"5775","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5775"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00005775","sets":["14:923:1549:1558","21:3039:3109:3142"]},"author_link":["8835","8837","8836","8833","8834"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"16","bibliographicPageStart":"9","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"近畿大学生物理工学部紀要"},{"bibliographic_title":"Memoirs of the Faculty of Biology-Oriented Science and Technology of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[要旨]トウダイグサ科の落葉低木であるJatropha curcasは, 種子に豊富な中性脂質を含み, 荒廃地でも生育可能であるため次世代バイオディーゼル原料植物として有望視されている。しかし一方で, 本植物の種子には発がんプロモーターであるphorbol ester類を含んでおり, 生産者や消費者の健康に与える負の影響が懸念されている。本研究ではJ. curcas 種子抽出物の発がんプロモーション活性を, マウスを用いた二段階発がん試験およびEBV早期抗原誘導活性を指標としたアッセイ系により評価した。その結果, J. curcas種子抽出物の発がんプロモーション活性は, 発がんプロモーション活性を有する代表的なホルポールエステルであるphorbol-12-myristate-13-acetate(PMA)より低いことが見いだされた。また，種子抽出物はPMAの発がん活性を抑制することが示された。これらの結果から, J. curcas種子抽出物には化学発がんを抑制する物質が含まれることが示唆された。              [Abstract] Jatr•opha eurcas, a tropical plant belonging to the family of Euphorbiaceac, has recently been attracted the considerable attention as a potential source for bio-diesel due to the high adaptability to semi-arid areas and the high oil content in seed kernel. The seed, however, contains phorbol esters which exhibit tumor-promoting activity, and thus negative impact of these compounds on health of producers or consumers should be concerned_ In this study, tumor-promoting activity of I cur eas seed extracts was evaluated by the two-stage mouse skin tumorgenesis assay and Epstein-Barr virus early antigen induction assay. Our results showed that tumor-promoting activity of J. curcas seed extracts was significantly lower than phorbol-l2-myristate-1 3-acetate (PMA), which is well known as a potent tumor promotor. In addition, J. cur eas seed extracts were revealed to suppress the tumor-promoting activity ofPMA. These results suggest that./ curcas seed extracts contain some suppressor of tumorgenesis.","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学生物理工学部"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13427202","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Matsukawa, Tetsuya"},{"subitem_text_language":"en","subitem_text_value":"Shoda, Masahiro"},{"subitem_text_language":"en","subitem_text_value":"Tamaki, Keiko"},{"subitem_text_language":"en","subitem_text_value":"Murakami, Hikaru"},{"subitem_text_language":"en","subitem_text_value":"Kajiyama, Shinichiro"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学生物理工学部生物工学科"},{"subitem_text_value":"近畿大学生物理工学部生物工学科"},{"subitem_text_value":"近畿大学生物理工学部生物工学科"},{"subitem_text_value":"近畿大学生物理工学部生物工学科"},{"subitem_text_value":"近畿大学生物理工学部生物工学科"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Biotechnological Science, Kinki University"},{"subitem_text_value":"Department of Biotechnological Science, Kinki University"},{"subitem_text_value":"Department of Biotechnological Science, Kinki University"},{"subitem_text_value":"Department of Biotechnological Science, Kinki University"},{"subitem_text_value":"Department of Biotechnological Science, Kinki University"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松川,  哲也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"正田,  将大"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"玉置,  恵子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村上,  ひかる"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"梶山,  慎一郎"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AN11153712-20140331-0009.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN11153712-20140331-0009.pdf","url":"https://kindai.repo.nii.ac.jp/record/5775/files/AN11153712-20140331-0009.pdf"},"version_id":"8a3b8d8d-30d5-4a61-b132-722c965240fd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ホルボールエステル","subitem_subject_scheme":"Other"},{"subitem_subject":"発がんプロモーション活性","subitem_subject_scheme":"Other"},{"subitem_subject":"マウスニ段階発がん試験","subitem_subject_scheme":"Other"},{"subitem_subject":"EBV早期抗原誘導試験","subitem_subject_scheme":"Other"},{"subitem_subject":"Jatropha curcas","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phorbol esters,tumor-promoting activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tow-stage mouse skin tumorgenesis assay","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"EBV-EA induction assay","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マウス二段階発がん試験とEBV早期抗原誘導活性を指標としたJatropha curcas種子抽出物の発がんプロモーション活性評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス二段階発がん試験とEBV早期抗原誘導活性を指標としたJatropha curcas種子抽出物の発がんプロモーション活性評価"},{"subitem_title":"〈Original Papers〉 Evaluation of tumor promoting activity of Jatropha curcas seed extracts by the two-stage mouse skin tumorgenesis assay and Epstein-Barr virus early antigen induction assay.","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["1558","3142"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-04-22"},"publish_date":"2014-04-22","publish_status":"0","recid":"5775","relation_version_is_last":true,"title":["マウス二段階発がん試験とEBV早期抗原誘導活性を指標としたJatropha curcas種子抽出物の発がんプロモーション活性評価"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T19:20:00.937135+00:00"}