{"created":"2023-06-20T16:36:15.291957+00:00","id":5745,"links":{},"metadata":{"_buckets":{"deposit":"3271de4f-f2e4-49a6-a39b-b3e98fae8e65"},"_deposit":{"created_by":3,"id":"5745","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5745"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00005745","sets":["14:923:1549:1567","21:3039:3109:3137"]},"author_link":["8728","8731","8724","8727","8726","8729","8730","8733","8732","8725"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"28","bibliographicPageEnd":"39","bibliographicPageStart":"31","bibliographic_titles":[{"bibliographic_title":"Memoirs of the Faculty of Biology-Oriented Science and Technology of Kinki University"},{"bibliographic_title":"近畿大学 生物理工学部 紀要","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[要旨] 梅酢ポリフェノール抽出物は梅干し加工過程の副産物である梅酢より得られた粉末で、高い抗酸化活性と多くの機能性を有し、健康維持のための新規素材としての利用が期待されている。そこで、梅酢ポリフェノール抽出物の安全性に関する情報を得るために、ラット及びマウスを用いて、単回経口投与試験、28日経口投与試験、90日経口投与試験を実施した。さらにUMU一テストおよび小核試験で変異原性を検討した。  ラット単回投与試験では梅酢ポリフェノール抽出物は5000mg/kg体重の投与でも、急性毒性はまったく確認されず、連続投与試験においても1000mg/kg体重で毒性は認められなかった。変異原性も認められず、梅酢ポリフェノール抽出物の安全性は高いものと思われた。       [Abstract]    Umezu, a liquid by-product of the pickling process in ume-boshi(salted plum fruits), is widely used as a food source or additives in Japan. Umezu Polyphenol Extract from the liquid has been found to have strong antioxidant activity and various physiological functions, which naturally has attracted attention as a novel food source beneficial for human health.  To assess the safety of the Umezu Polyphenol Extract, orally administered single and 28-day repeated dose studies were carried out in rats and 90-day subchronic study was carried out in mice. In the single dose study, an approximate lethal dose was found to be greater than 5000mg/kgBW. In the repeated oral dose studies, the extract showed no significant clinical, hematological, chemical or histopathological effect at a dose of 1000mg/kgBW. Furthermore, both the chromosomal aberration test and the micronucleus test showed no significant mutagenicity. These results confirms thet the Umezu Polyphenol Extract appears to be a safe food source without toxicity.","subitem_description_type":"Abstract"}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Shiga, Yu-suke  Hara, Yu-dai","subitem_description_type":"Other"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学生物理工学部"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13427202","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Shiga, Yusuke"},{"subitem_text_language":"en","subitem_text_value":"Tsuchida, Tatsunori"},{"subitem_text_language":"en","subitem_text_value":"Hara, Yudai"},{"subitem_text_language":"en","subitem_text_value":"Kishida, Kunihiro"},{"subitem_text_language":"en","subitem_text_value":"Maeda, Masanobu"},{"subitem_text_language":"en","subitem_text_value":"Miyashita, Kazuhisa"},{"subitem_text_language":"en","subitem_text_value":"Fujiwara, Maki"},{"subitem_text_language":"en","subitem_text_value":"Yamanishi, Hisako"},{"subitem_text_language":"en","subitem_text_value":"Yano, Fumiko"},{"subitem_text_language":"en","subitem_text_value":"Mitanil, Takahiko"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学生物理工学部 食品安全工学科"},{"subitem_text_value":"近畿大学生物理工学部 生物工学科"},{"subitem_text_value":"近畿大学生物理工学部 生物工学科"},{"subitem_text_value":"近畿大学生物理工学部 食品安全工学科"},{"subitem_text_value":"和歌山県立医科大学医学部"},{"subitem_text_value":"和歌山県立医科大学医学部"},{"subitem_text_value":"和歌山県工業技術センター"},{"subitem_text_value":"和歌山県工業技術センター"},{"subitem_text_value":"近畿大学生物理工学部 食品安全工学科"},{"subitem_text_value":"近畿大学生物理工学部 食品安全工学科"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"志賀,  勇介"},{"creatorName":"シガ, ユウスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土田,  辰典"},{"creatorName":"ツチダ, タツノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原,  雄大"},{"creatorName":"ハラ, ユウダイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岸田,  邦博"},{"creatorName":"キシダ, クニヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"前田,  正信"},{"creatorName":"マエダ, マサノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮下,  和久"},{"creatorName":"ミヤシタ, カズヒサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤原,  真紀"},{"creatorName":"フジワラ, マキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山西,  妃早子"},{"creatorName":"ヤマニシ, ヒサコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"矢野,  史子"},{"creatorName":"ヤノ, フミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三谷,  隆彦"},{"creatorName":"ミタニ, タカヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AA11153712-20110930-0031.pdf","filesize":[{"value":"737.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AA11153712-20110930-0031.pdf","url":"https://kindai.repo.nii.ac.jp/record/5745/files/AA11153712-20110930-0031.pdf"},"version_id":"bd776571-d6e3-43b2-8964-4ee943582104"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈Original Papers〉梅酢ポリフェノール抽出物の安全性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈Original Papers〉梅酢ポリフェノール抽出物の安全性の検討"},{"subitem_title":"〈Original Papers〉Safety studies of Umezu Polyphenol Extract","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["1567","3137"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-27"},"publish_date":"2011-10-27","publish_status":"0","recid":"5745","relation_version_is_last":true,"title":["〈Original Papers〉梅酢ポリフェノール抽出物の安全性の検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T19:20:31.398088+00:00"}