{"created":"2023-06-20T16:35:53.995906+00:00","id":5345,"links":{},"metadata":{"_buckets":{"deposit":"fa874f31-bf4e-49d6-8d8d-d7b3884e880a"},"_deposit":{"created_by":3,"id":"5345","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5345"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00005345","sets":["14:923:1379:1383"]},"author_link":["42977","42976","42973","42974","42975"],"item_2_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"境界域及び軽度コレステロール血症患者の血清LDL-コレステロール値はキトサン入りカプセル摂取で減少する"}]},"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"近畿大学農学部紀要"},{"bibliographic_title":"MEMOIRS OF THE FACULTY OF AGRICULTURE OF KINKI UNIVERSITY","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"<Synopsis>In the form of a clinical study, this study aimed to determine the efficacy and safety of chitosan in reducing LDL-cholesterol in patients having slightly above normal low-density lipoprotein cholesterol serum levels (LDL-cholesterol) who also were diagnosed with slightly high hypercholesterolemia. There were three groups of subjects in the randomized, double-blinded, placebo-controlled trial. Group 1 was provided with two chitosan capsules (580 mg/day). Group 2 was given four chitosan capsules (1,160 mg/day). Group 3 was given a placebo. The subjects began taking the chitosan capsules on a specified day, filled in the Intake Diary, and continued taking the capsules for 12 weeks. After beginning the chitosan capsule intake, the subjects came to the hospital after four weeks, eight weeks, and twelve weeks and were given blood tests and urine tests. Their body measurements were also taken and medical staff interviewed the subjects to confirm that they were continuing to take the chitosan supplements as prescribed. Results from the eighth week showed that the LDL-cholesterol of the men with more than 140 mg/㎗ of LDL-cholesterol at the baseline who took in 1,160 mg/day of chitosan was significantly reduced when compared to the LDL-cholesterol of the subjects who took the placebo (p＜0.05). In addition, the chitosan supplements were effective in lowering levels of the LDL-cholesterol and no side effects were noticeable. The results suggest that chitosan supplements are effective and safe.          \n<要約>境界領域および軽度コレステロール血症患者の血清低密度リポタンパク質コレステロール値(LDL コレステロール）の人々に対するキトサン約290 mg を含むカプセル摂取の影響および安全性を検討した。 2 個のキトサン・カプセル(580 mg/日) および4個のキトサン・カプセル(1,160 mg/日) の2用量を用いて, 無作為化, 2重盲検化, プラセボ対照法で行なった。 ボランティアの被験者は, 医師による面接および身体測定, 血液検査［血液生化学検査, 一般的な血液検査］, 尿検査および健康診断を行なった。 これらのデータ（ベースライン）によって, 被験者にキトサン・カプセルを割り付け配布した。 被験者はキトサン・カプセル摂取を始めたときから摂取日記に書き入れ, 12週間継続した。 キトサン・カプセル摂取後の被験者は4 週目, 8週目, 12週目に血液検査, 尿検査および身体測定が実行された。 被験者はまた, 面接によって, 日常習慣に何か変化がなかったか確認した。 1,160 mg/日のキトサンを摂取した被験者のLDL コレステロールは, 8週目にplaceboを摂取した被験者のLDL コレステロールと比較して, 減少傾向が見られた(p＜0.1）。1,160 mg/日のキトサンを摂取したベースライン時に140 mg/㎗ 以上のLDLコレステロール群のLDL コレステロールは、placeboを摂取した被験者のLDLコレステロールと比較すると, 8週目に著しく減少した(p＜0.05)。 キトサン食品摂取は, 医学上問題になる所見や因果関係を示す事実がなく, 副作用に関してもほとんど問題となることはなかった。 これらからキトサン食品の摂取は, 血清LDL-コレステロール値を低下させる補助食品となることが示唆された。","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学農学部"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"4538889","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YOSHIKAWA, Kentaro"},{"subitem_text_language":"en","subitem_text_value":"IWASAKI, Harumi"},{"subitem_text_language":"en","subitem_text_value":"KABA, Naoko"},{"subitem_text_language":"en","subitem_text_value":"KOHRI, Toshiyuki"},{"subitem_text_language":"en","subitem_text_value":"MUI, Kayo"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学部食品栄養学科公衆栄養学研究室"},{"subitem_text_value":"近畿大学農学部食品栄養学科公衆栄養学研究室"},{"subitem_text_value":"近畿大学農学部食品栄養学科公衆栄養学研究室"},{"subitem_text_value":"近畿大学農学部食品栄養学科公衆栄養学研究室"},{"subitem_text_value":"大阪市健康局健康推進部"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Food and Nutorition, Kinki University"},{"subitem_text_value":"Department of Food and Nutorition, Kinki University"},{"subitem_text_value":"Department of Food and Nutorition, Kinki University"},{"subitem_text_value":"Department of Food and Nutorition, Kinki University"},{"subitem_text_value":"Osaka city, Public Health Burear, Public Health Division"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉川, 賢太郎"},{"creatorName":"ヨシカワ, ケンタロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩崎, はるみ"},{"creatorName":"イワサキ, ハルミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"蒲, 尚子"},{"creatorName":"カバ, ナオコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"郡, 俊之"},{"creatorName":"コオリ, トシユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"撫井, 賀代"},{"creatorName":"ムイ, カヨ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AN00064044-20140331-0001.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00064044-20140331-0001.pdf","url":"https://kindai.repo.nii.ac.jp/record/5345/files/AN00064044-20140331-0001.pdf"},"version_id":"dd5ca444-44a9-4429-83ad-14550066173b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"chitosan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LDL-cholesterol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Randomized Controlled Trial","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈Original〉Lowering serum LDL-cholesterol in mild hypercholesterolemia patients with chitosan capsules","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈Original〉Lowering serum LDL-cholesterol in mild hypercholesterolemia patients with chitosan capsules","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["1383"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-21"},"publish_date":"2014-06-21","publish_status":"0","recid":"5345","relation_version_is_last":true,"title":["〈Original〉Lowering serum LDL-cholesterol in mild hypercholesterolemia patients with chitosan capsules"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T19:55:51.404030+00:00"}