{"created":"2023-06-20T16:35:33.132670+00:00","id":4909,"links":{},"metadata":{"_buckets":{"deposit":"3df477bf-2cde-4ad3-9cca-ba1473b4361d"},"_deposit":{"created_by":3,"id":"4909","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4909"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00004909","sets":["14:923:1379:1419","21:3039:3040:3052"]},"author_link":["6709","6710","6708"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"29","bibliographicPageEnd":"67","bibliographicPageStart":"63","bibliographic_titles":[{"bibliographic_title":"近畿大学農学部紀要"},{"bibliographic_title":"Memoirs of the Faculty of Agriculture of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Author Abstract]Aloe-emodin isolated from Aloe arborescens Mill, inhibits frameshift mutations caused by 3-amino-l-methyl-5H-pyrido[4,3b]indole in Salmonella typhimurium TA98. We examined the relationship between the antimutagenicity of aloe-emodin and its derivatives by a modification of the Ames test. All but anthraquinone itself could inhibit frameshift mutation by at least 80% if the amount used was at least 10^<-3> mol/plate, but the numbers of revertant colonies was almost unchanged at this dose. The pattern of inhibition suggested that substitutions such as hydroxyl and hydroxymethyl groups on aromatic rings were important for the activity. Furthermore, five species of medicinal plants contained ahthraquinones that also inhibited frameshift mutation.[著者抄録]筆者らはアロエ植物の抗変異原性を検討し,その活性成分がアントラキノンの一種で寫下活性成分としてよく知られている非糖体aloe-emodinであって,その配糖体のbarbaloinには全く活性が認められないことを前報で述べた。そこで本研究では,非糖体アントラキノン類の抗変異原活性をより明らかにするためaloe-emodin関連のアントラキノン類の抗変異原活性をAmes法変法によって調べた。その結果,芳香環上に置換基を持たないanthraquinoneを除き,供試した他のすべてのアントラキノン類にaloe-emodinと同様の非常に強い抗変異原性が認められた。これら強い活性を示したアントラキノン類の大半のものは芳香環上に水酸基を有していることから,活性発現にそれがどの様に係わっているかをさらに詳しく調べる必要がある。また,今回強い抗変異原性の認められたアントラキノン類のいくつかを含むことが知られている5種類の生薬を用いその抗変異原活性を検討した。その結果,いずれも非常に強い抗変異原注を示した。これら生薬には本実験で供試したアントラキノン類以外にも多種多様のアントラキノン類が微量成分として含まれているので,それらの活性についても検討する必要がある。","subitem_description_type":"Abstract"}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"記事区分：原著","subitem_description_type":"Other"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学農学部"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04538889","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Nakasugi, Toru"},{"subitem_text_language":"en","subitem_text_value":"Nishida, Kenji"},{"subitem_text_language":"en","subitem_text_value":"Komai, Koichiro"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学部農芸化学科"},{"subitem_text_value":"近畿大学農学部農芸化学科農薬化学研究室"},{"subitem_text_value":"近畿大学農学部農芸化学科農薬化学研究室"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University"},{"subitem_text_value":"Laboratory of Pesticide Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University"},{"subitem_text_value":"Laboratory of Pesticide Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中杉,  徹"},{"creatorName":"ナカスギ, トオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西田,  憲司"},{"creatorName":"ニシダ, ケンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"駒井,  功一郎"},{"creatorName":"コマイ, コウイチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AN00064044-19960315-0063.pdf","filesize":[{"value":"887.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00064044-19960315-0063.pdf","url":"https://kindai.repo.nii.ac.jp/record/4909/files/AN00064044-19960315-0063.pdf"},"version_id":"4b3f7ebf-f25a-40c8-a515-d9e687ec6284"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_thumbnail":{"attribute_name":"サムネイル","attribute_value_mlt":[{"subitem_thumbnail":[{"thumbnail_label":"AN00064044-19960315-0063.jpeg","thumbnail_url":"/api/files/3df477bf-2cde-4ad3-9cca-ba1473b4361d/AN00064044-19960315-0063.jpeg?versionId=a89bd183-254b-4980-bb8e-cf8d0181694d"}]}]},"item_title":"アントラキノン類の抗変異原性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アントラキノン類の抗変異原性"},{"subitem_title":"Antimutagenicity of Anthraquinones","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["1419","3052"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-28"},"publish_date":"2008-01-28","publish_status":"0","recid":"4909","relation_version_is_last":true,"title":["アントラキノン類の抗変異原性"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T19:29:17.829598+00:00"}