{"created":"2023-06-20T16:35:31.892732+00:00","id":4880,"links":{},"metadata":{"_buckets":{"deposit":"bce54eae-c9a2-4720-a7a0-16a4ea773131"},"_deposit":{"created_by":3,"id":"4880","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4880"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00004880","sets":["14:923:1379:1415","21:3039:3040:3050"]},"author_link":["6624","6621","6622","6623"],"item_2_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of sesamin and related lignan compounds on fatty acid metabolism in Hep G2 cell"}]},"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"31","bibliographicPageEnd":"40","bibliographicPageStart":"35","bibliographic_titles":[{"bibliographic_title":"近畿大学農学部紀要"},{"bibliographic_title":"Memoirs of the Faculty of Agriculture of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Author Abstract]The effects of sesamin and episesamin, lignan compounds which are present in sesame seeds, on fatty acid biosynthesis, and on the docosahexaenoic acid (DHA) biosynthetic pathway in particular, were investigated in the human hepatoma cell line, Hep G2. Eicosapentaenoic acid (EPA), sesamin and episesamin were incorporated into the cell depending upon their concentrations, and EPA was metabolised into docosapentaenoic acid (DPA) and DHA. However, no significant changes in fatty acid composition were observed. This result indicates that sesamin and episesamin do not inhibit the biosynthesis of DHA from EPA.[著者抄録]ヒト肝癌由来培養細胞株Hep G2は, 培地に添加したエイコサペンタエン酸(EPA)を, 濃度依存的に細胞内に取り込むことが確認された。また, 微弱ではあるが低濃度(添加量40μM以下)においては濃度依存的にドコサヘキサエン酸(DHA)へと変換する事が確認され, Hep G2細胞にはEPAからDHAを生合成する経路が存在することが確認された。また, 胡麻に含まれるリグナン類であるセサミンおよびその鏡像異性体であるエピセサミンは添加濃度に依存して細胞内への取り込まれることが確認されたが, 添加による脂肪酸組成の顕著な変化は認められず, Hep G2細胞におけるEPAからのDHAの生成を阻害するという結果は得られなかった。","subitem_description_type":"Abstract"}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"記事区分：原著","subitem_description_type":"Other"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学農学部"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04538889","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Shirasaka, Norifumi"},{"subitem_text_language":"en","subitem_text_value":"Sayo, Chizuko"},{"subitem_text_language":"en","subitem_text_value":"Murakami, Tetsuo"},{"subitem_text_language":"en","subitem_text_value":"Yoshizumi, Hajime"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学部食品栄養学科"},{"subitem_text_value":"近畿大学農学部食品栄養学科"},{"subitem_text_value":"近畿大学農学部食品栄養学科"},{"subitem_text_value":"近畿大学農学部食品栄養学科"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Depertment of Food science and Nutrition, Fuculty of Agriculture, Kinki university"},{"subitem_text_value":"Depertment of Food science and Nutrition, Fuculty of Agriculture, Kinki university"},{"subitem_text_value":"Depertment of Food science and Nutrition, Fuculty of Agriculture, Kinki university"},{"subitem_text_value":"Depertment of Food science and Nutrition, Fuculty of Agriculture, Kinki university"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白坂,  憲章"},{"creatorName":"シラサカ, ノリフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐用,  知寿子"},{"creatorName":"サヨウ, チズコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村上,  哲男"},{"creatorName":"ムラカミ, テツオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉栖,  肇"},{"creatorName":"ヨシズミ, ハジメ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AN00064044-19980331-0035.pdf","filesize":[{"value":"982.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00064044-19980331-0035.pdf","url":"https://kindai.repo.nii.ac.jp/record/4880/files/AN00064044-19980331-0035.pdf"},"version_id":"b711955a-0090-4c55-b3f1-301fad4f46c0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_thumbnail":{"attribute_name":"サムネイル","attribute_value_mlt":[{"subitem_thumbnail":[{"thumbnail_label":"AN00064044-19980331-0035.jpeg","thumbnail_url":"/api/files/bce54eae-c9a2-4720-a7a0-16a4ea773131/AN00064044-19980331-0035.jpeg?versionId=8bc707e1-4619-4689-a846-9dbda5ad2daa"}]}]},"item_title":"ヒト肝癌由来培養細胞株Hep G2の高度不飽和脂肪酸生合成系へのゴマリグナン類の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト肝癌由来培養細胞株Hep G2の高度不飽和脂肪酸生合成系へのゴマリグナン類の影響"}]},"item_type_id":"2","owner":"3","path":["1415","3050"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-28"},"publish_date":"2008-01-28","publish_status":"0","recid":"4880","relation_version_is_last":true,"title":["ヒト肝癌由来培養細胞株Hep G2の高度不飽和脂肪酸生合成系へのゴマリグナン類の影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T00:57:11.917964+00:00"}