{"created":"2023-06-20T16:34:23.803967+00:00","id":3578,"links":{},"metadata":{"_buckets":{"deposit":"52b75593-49ee-4141-ad16-5e3dff1f3d05"},"_deposit":{"created_by":3,"id":"3578","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3578"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003578","sets":["14:2667:2675:2679:2683","21:2669:2677:2681:2684"]},"author_link":["3519"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Roles of novel NADPH oxidase regulater, Poldip2, in renal pahophysiology"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"3","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：NADPHオキシダーゼの新規制御因子であるPoldip2は、腎内では糸球体(メサンジウム細胞および上皮細胞)や皮質および髄質集合管において発現していることが確認された。さらに、糖尿病モデルマウスでは週齢が進むにつれてその腎内での発現が低下していた。一方、高血圧モデルラットの腎においては、週齢とともに増加していた。培養細胞を用いた実験において、トランスフォーミング増殖因子(TGF-β)によりPoldip2蛋白発現が充進することが明らかとなった。    研究成果の概要（英文）： Podip2, a regulator for NADPH oxidase, is localized to glomerular cells, and epithelium of cortical and modularly collecting ducts. Its expression is upregulated in a diabetic animal model according to age. Contrary, it is downregulated in a hypertensive animal model. Transforming growth factor-β stimulates its  expression in a cell culture system.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：基盤研究(C);  研究期間：2010～2012;   課題番号：22590918;   研究分野：腎臓内科学;   科研費の分科・細目：腎臓学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/70441079.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TANIYAMA, YOSHIHIRO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"谷山,  佳弘"},{"creatorName":"タニヤマ, ヨシヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22590918seika.pdf","filesize":[{"value":"599.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22590918seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3578/files/KAKEN_22590918seika.pdf"},"version_id":"95cb169c-8e37-42c5-bc43-63aafca53f75"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ADPHオキシダーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病性腎症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"NADPHオキシダーゼ新規制御因子Poldip2の腎病態生理における役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NADPHオキシダーゼ新規制御因子Poldip2の腎病態生理における役割の解明"}]},"item_type_id":"8","owner":"3","path":["2683","2684"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-25"},"publish_date":"2013-07-25","publish_status":"0","recid":"3578","relation_version_is_last":true,"title":["NADPHオキシダーゼ新規制御因子Poldip2の腎病態生理における役割の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:30:54.367007+00:00"}