{"created":"2023-06-20T16:34:23.294063+00:00","id":3567,"links":{},"metadata":{"_buckets":{"deposit":"73362c81-e44b-4358-a907-948220d6c4b7"},"_deposit":{"created_by":3,"id":"3567","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3567"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003567","sets":["14:2667:2675:2679:2683","21:2669:2677:2681:2684"]},"author_link":["4278","4277","4276"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Research on regenerative medicine of pediatric airways with functional laminar structure"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 本研究では、家兎の耳介軟骨より作製した軟骨シートを用い、これを我々が開発したin vitroにおける回転培養法にて足場を用いない円筒状構造物として再生させた上で、さらに繊維芽細胞層、円柱繊毛上皮層という機能の異なる層構造を有する細胞シートを作製した。この細胞シート群を、種類の異なる細胞を層状に培養する目的で開発された細胞積層化技術を応用して、外層に繊維芽細胞層、中層に軟骨細胞層、内層に円柱繊毛上皮層を積層化し、回転培養法で円筒状の機能的構造体とすることを試みたが現時点では困難であった。本法によって機能的層構造を有した気管の再生が可能となれば、小児のように広範囲の気管を再生気管によって置換する治療法への道が開かれると考えられる。   研究成果の概要（英文）： Auricular chondrocytes were harvested from rabbits and cultivated to form a chondrocyte sheet. We manufactured cylindrical cartilage structure from the sheet by the in vitro roller tube culture. Furthermore, we made the fibroblast layer sheet and column cilia epithelial layer sheet with the different function that varied in each. We tried laminating these three kinds of seats (We placed column cilia epithelial layers, a cartilage cell layer and the fibroblast layer sequentially from the inside), and tried to manufacture cylindrical functional structure, however resulted in failure of regeneration. If tracheal regeneration having functional laminar structure is enabled by this method, a new therapy for pediatric airway disease will be developed using the regeneration trachea.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：基盤研究(C);  研究期間：2010～2012;   課題番号：22591978;   研究分野：医歯薬学;   科研費の分科・細目：外科系臨床医学・小児外科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/20403074.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/30273626.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/60467561.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者(H23年まで研究分担者として参画)"},{"subitem_text_value":"研究分担者(H22年まで研究分担者として参画)"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAMIYAMA, MASAFUMI"},{"subitem_text_language":"en","subitem_text_value":"USUI, NORIAKI"},{"subitem_text_language":"en","subitem_text_value":"TANI, GAKUTO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部附属病院; 講師"},{"subitem_text_value":"大阪大学医学系研究科; 准教授"},{"subitem_text_value":"大阪大学医学部附属病院; 医員"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"神山,  雅史"},{"creatorName":"カミヤマ, マサフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4276","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60467561","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"臼井,  規朗"},{"creatorName":"ウスイ, ノリアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷,  岳人"},{"creatorName":"タニ, ガクト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4278","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22591978seika.pdf","filesize":[{"value":"22.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22591978seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3567/files/KAKEN_22591978seika.pdf"},"version_id":"d6f8035b-e35c-4960-aafe-6878ee52761b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"再生医療","subitem_subject_scheme":"Other"},{"subitem_subject":"機能的層構造","subitem_subject_scheme":"Other"},{"subitem_subject":"気管軟骨","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞積層化","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞シート工学","subitem_subject_scheme":"Other"},{"subitem_subject":"Tissue engineering","subitem_subject_scheme":"Other"},{"subitem_subject":"Cylindrical cartilage","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"機能的層構造を有する小児の気管再生法に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"機能的層構造を有する小児の気管再生法に関する研究"}]},"item_type_id":"8","owner":"3","path":["2683","2684"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-25"},"publish_date":"2013-07-25","publish_status":"0","recid":"3567","relation_version_is_last":true,"title":["機能的層構造を有する小児の気管再生法に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:31:15.155820+00:00"}