{"created":"2023-06-20T16:34:23.229814+00:00","id":3566,"links":{},"metadata":{"_buckets":{"deposit":"cde8ecfe-710b-441a-862c-bd18008aab2d"},"_deposit":{"created_by":3,"id":"3566","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3566"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003566","sets":["14:2667:2675:2679:2683","21:2669:2677:2681:2684"]},"author_link":["4259"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Imaging of proliferative ability and hypoxia of tumor in radioimmunotherapy"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： イットリウム-90標識抗CD20抗体イブリツモマブ  チウキセタンによって治療を受けたCD20陽性B細胞性非ポジキンリンパ腫症例において、治療前後にFDGによる糖代謝やFMIS0による低酸素のPET/CTイメージングを実施し、その変化を経時的に評価した。またIn-111標識抗CD20抗体のSPECT/CTを用いたイメージングによって抗原発現も評価した。これら糖代謝、低酸素状態、CD20の発現と、Y-90標識抗体による治療効果との関連について解析した。            研究成果の概要（英文）：In patients with CD20 positive B—cell non—Hodgkin lymphoma who underwent yttrium-90 labeled anti—CD20 ibritumomab tiuxetan therapy, glucose metabolism by FDG and hypoxia by FMISO were evaluated with PET/CT before and after therapy, and changes were analyzed over time. Antigen expression of CD20 was also evaluated by SPECT/CT using indium-111 labeled anti—CD20 antibody. Association of glucose metabolism, hypoxia, and CD20 expression with therapeutic response was analyzed.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：基盤研究（C）;  研究期間：2009～2012;     課題番号：21591580;   研究分野：医師薬学;   科研費の分科・細目： 内科系臨床医学・放射線科学;   細野, 眞","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/00281303.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"HOSNO, MAKOTO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部附属病院; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"細野,  真"},{"creatorName":"ホソノ, マコト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_21591580seika.pdf","filesize":[{"value":"820.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_21591580seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3566/files/KAKEN_21591580seika.pdf"},"version_id":"af089775-4d6a-4ccc-9498-24cb78983895"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"放射免疫療法","subitem_subject_scheme":"Other"},{"subitem_subject":"低酸素","subitem_subject_scheme":"Other"},{"subitem_subject":"悪性リンパ腫","subitem_subject_scheme":"Other"},{"subitem_subject":"抗原抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"陽電子断層撮影","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"放射免疫療法における腫瘍増殖能・低酸素状態の画像化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射免疫療法における腫瘍増殖能・低酸素状態の画像化"}]},"item_type_id":"8","owner":"3","path":["2683","2684"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-25"},"publish_date":"2013-07-25","publish_status":"0","recid":"3566","relation_version_is_last":true,"title":["放射免疫療法における腫瘍増殖能・低酸素状態の画像化"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:31:18.737243+00:00"}