{"created":"2023-06-20T16:34:23.165864+00:00","id":3565,"links":{},"metadata":{"_buckets":{"deposit":"b2b7d43b-84d1-4ebb-b528-20d4046fcaea"},"_deposit":{"created_by":3,"id":"3565","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3565"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003565","sets":["14:2667:2675:2679:2683","21:2669:2677:2681:2684"]},"author_link":["4275","4274"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Pre-clinical applications using PTEN-knockout prostate cancer mouse model"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： われわれは以前にPSA コンディショナルPTEN ノックアウトマウスを確立し、ヒト前立腺癌の発生・治療など多岐にわたる研究に対して有用であることを検証してきた。今回PTEN flox/PSA-Cre マウス前立腺発癌モデルにおいて、抗アンドロゲン薬・分子標的薬の単剤およびコンビネーション療法にてIntervention療法としての有効性について検討し、MEK 阻害剤AZD6244 やJAK/STAT シグナル阻害剤AZD1480 についても同様の研究を行い、有意な抗腫瘍効果を認めた。また、癌組織を用いたAdipokine profile の検討で発見したLeptin とCRPC モデルを用いて行ったDNA マイクロアレイから得られた細胞外マトリックス蛋白であるLumican やHOXA10 についても検討し、予後を決定するバイオマーカとして有用であると思われた。これらの結果については日本癌学会、泌尿器科学会、103回アメリカ癌学会（AACR）などにおいて報告した。      研究成果の概要（英文）：To better understand the disease process of prostate cancer, we have developed a prostate-specific conditional knockout mouse model that targets the PTEN tumor suppressor gene. Our model is based on PSA-Cre recombinase driven inactivation of Pten to alter PI3K/Akt/mTOR signaling specific to the prostate, resulting in a stage-specific development and progression of cancer that mimics humans recapitulating various stages of disease progression ranging from precancerous PIN lesions to castration resistant prostate cancer. We performed several experiments that demonstrate the versatility and usefulness of this model for validation of preclinical targeted intervention, biomarker discovery (leptin, lumican and HOXA10) and characterizing lifestyle behavior effects on cancer progression.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：基盤研究（C);  研究期間：2010～2012;   課題番号：22591781;   研究分野：医歯薬学;   科研費の分科・細目：外科系臨床医学・泌尿器科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/20449838.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/90213397.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"DEVELASCO, MARCO"},{"subitem_text_language":"en","subitem_text_value":"UEMURA, HIROTSUGU"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部: 助教"},{"subitem_text_value":"近畿大学医学部: 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"デベラスコ,  マルコ"},{"creatorName":"デベラスコ, マルコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"植村,  天受"},{"creatorName":"ウエムラ, ヒロツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22591781seika.pdf","filesize":[{"value":"235.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22591781seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3565/files/KAKEN_22591781seika.pdf"},"version_id":"e6b53819-bc7a-47ba-ad04-10d6e9d080cd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"前立腺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"PTEN","subitem_subject_scheme":"Other"},{"subitem_subject":"ノックアウトマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"動物モデル","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"PTEN ノックアウトマウス前立腺癌モデルを用いたpre-clinical 研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PTEN ノックアウトマウス前立腺癌モデルを用いたpre-clinical 研究"}]},"item_type_id":"8","owner":"3","path":["2683","2684"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-25"},"publish_date":"2013-07-25","publish_status":"0","recid":"3565","relation_version_is_last":true,"title":["PTEN ノックアウトマウス前立腺癌モデルを用いたpre-clinical 研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:31:20.828077+00:00"}