{"created":"2023-06-20T16:34:23.102469+00:00","id":3564,"links":{},"metadata":{"_buckets":{"deposit":"ea9cca31-e644-44f2-ab82-92bec4052854"},"_deposit":{"created_by":3,"id":"3564","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3564"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003564","sets":["14:2667:2675:2679:2683","21:2669:2677:2681:2684"]},"author_link":["4273"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Involvement of receptor for advanced glycation end products for hyperglycemia—induced aggravation of white matter damage by cerebral ischemia"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 急性糖負荷によるラット急性高血糖モデル(2g/kgのブドウ糖液を腹腔内投与)を用いて、5分間の心肺停止・蘇生を行い2週間後に脳スライスを作成した。心肺停止・蘇生により2週間後までに、海馬CA1領域にミクログリアの活性化、神経細胞の傷害、神経軸索の傷害と最終糖化産物受容体(RAGE : receptor for advanced glycation end products)の発現が認められた。が、非糖負荷群との有意差は確認できなかった。また神経学的機能検査でも、シャム手術群や非糖負荷群と糖負荷群との間に差異は認められなかった。その理由として、十分な標本数でないことや糖負荷をしなくても心肺停止・蘇生のみで血糖がかなり上がること、などが考えられる。      研究成果の概要（英文）： Global cerebral ischemia was induced by 5 min of cardiac arrest and resuscitation (CAR) inmate rats with or without acute glucose administration (2g/kg i.p.). Two weeks after the CAR, the brain was extracted and brain slices were prepared. Microglial activation, neuronal and axonal injuries, and RAGE (receptor for advanced glycation end products) expression were detected in the hippocampal CAI region in both groups, i.e., a glucose-administered group and a vehicle-administered group, but the statistically significant differences of those were not detected between the two groups. Neurologic deficit scores, which can detect functional damage in the brain, were similar in the both groups. I assume that the reason is due to the fact that sample size was not enough or that CAR alone caused rather hyperglycemia.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：基盤研究(C);  研究期間：2010～2012;   課題番号：22591720;   研究分野：医歯薬学;   科研費の分科・細目：外科系臨床医学・麻酔科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/10207714.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NAKAO, SHINICHI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中尾,  慎一"},{"creatorName":"ナカオ, シンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22591720seika.pdf","filesize":[{"value":"776.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22591720seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3564/files/KAKEN_22591720seika.pdf"},"version_id":"83839dc9-c4db-4244-8105-3edc33a98ca4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"全脳虚血","subitem_subject_scheme":"Other"},{"subitem_subject":"高血糖","subitem_subject_scheme":"Other"},{"subitem_subject":"脳白質","subitem_subject_scheme":"Other"},{"subitem_subject":"活性酸素","subitem_subject_scheme":"Other"},{"subitem_subject":"糖化最終産物","subitem_subject_scheme":"Other"},{"subitem_subject":"RAGE (receptor for advanced glycation end products)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"高血糖の脳虚血白質傷害における最終糖化産物受容体の関与とその治療に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高血糖の脳虚血白質傷害における最終糖化産物受容体の関与とその治療に関する研究"}]},"item_type_id":"8","owner":"3","path":["2683","2684"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-25"},"publish_date":"2013-07-25","publish_status":"0","recid":"3564","relation_version_is_last":true,"title":["高血糖の脳虚血白質傷害における最終糖化産物受容体の関与とその治療に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:31:24.893467+00:00"}