{"created":"2023-06-20T16:34:22.603897+00:00","id":3556,"links":{},"metadata":{"_buckets":{"deposit":"65167192-d4f5-4a4a-9736-8688e3a5ac82"},"_deposit":{"created_by":3,"id":"3556","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3556"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003556","sets":["14:2667:2675:2679:2683","21:2669:2677:2681:2684"]},"author_link":["4251"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Enhancement of utility of  imaging mass spectrometry in pathophysiological examination"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究は新たな疾患組織検査手法として、質量顕微鏡法の実用性を向上させることを目的とするものである。質量顕微鏡法は組織切片を二次元に質量分析することによって、組織切片に存在する生体分子の局在を可視化する手法である。疾患検査法として質量顕微鏡法の実用性を判断するためには、多くの疾患に適用が可能であることを示すことが重要である。本研究期間にATGL変異症、粥状動脈硬化病巣、腹部大動脈瘤(AAA)の解析法を検討し、疾患発症時の代謝変動などを可視化した。   研究成果の概要（英文）：The aim of this study is to enhance utility of imaging mass spectrometry (IMS) as new pathophysiological examination. IMS is a two-dimensional MS technique used to visualize the spatial distribution of biomolecules without extraction, purification, separation, or labeling of biological samples. It is important to estimate general versatility of IMS. In thisstudy, we try to visualize the metabolic variation of diseases, including ATGL mutant disease, atherosclerosis, and abdominal aortic aneurysm. We succeed to find some characteristic changes in disease tissues by using IMS.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：基盤研究(C);  研究期間：2010～2012;   課題番号：22590522;   研究分野：病態検査学;   科研費の分科・細目：境界医学、病態検査学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/40455572.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ZAIMA, NOBUHIRO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"財満,  信宏"},{"creatorName":"ザイマ, ノブヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4251","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40455572","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22590522seika.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22590522seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3556/files/KAKEN_22590522seika.pdf"},"version_id":"f8b9552d-6633-4d30-8b50-6561100f9680"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"質量顕微鏡法","subitem_subject_scheme":"Other"},{"subitem_subject":"イメージング","subitem_subject_scheme":"Other"},{"subitem_subject":"イメージングマススペクトロメトリー","subitem_subject_scheme":"Other"},{"subitem_subject":"ATGL変異症","subitem_subject_scheme":"Other"},{"subitem_subject":"動脈硬化","subitem_subject_scheme":"Other"},{"subitem_subject":"疾患検査","subitem_subject_scheme":"Other"},{"subitem_subject":"質量分析","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"質量顕微鏡を用いた新規疾患解析手法の実用性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"質量顕微鏡を用いた新規疾患解析手法の実用性の検討"}]},"item_type_id":"8","owner":"3","path":["2683","2684"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-25"},"publish_date":"2013-07-25","publish_status":"0","recid":"3556","relation_version_is_last":true,"title":["質量顕微鏡を用いた新規疾患解析手法の実用性の検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:31:39.187449+00:00"}