{"created":"2023-06-20T16:34:22.515959+00:00","id":3554,"links":{},"metadata":{"_buckets":{"deposit":"7bd74452-25be-4dfe-a2f6-3bc9124c9f21"},"_deposit":{"created_by":3,"id":"3554","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3554"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003554","sets":["14:2667:2675:2679:2683","21:2669:2677:2681:2684"]},"author_link":["4248","4247","4249"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The role of mouse APOBEC3 in the regulation of endogenous retrovirus"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： マウスAPOBEC3は外来性のレトロウイルスの複製を制御する宿主因子であり、レトロウイルス自然抵抗性のC57BL/6（B6)系統では、抗ウイルス活性の高いAPOBEC3バリアントが多く発現している。B6マウスでは生後1年までにがんを発症することは稀であるが、APOBEC3欠損下では雌個体の一部で乳癌とリンパ性白血病の発症を認め、それら発症マウスでは内在性乳癌ウイルスmouse mammary tumor virus (MMTV)の転写産物が多く発現していた。本研究は、APOBEC3が内在性レトロウイルスの発現を制御することでがん発症を抑制している可能性を示した。   研究成果の概要（英文）：Mouse APOBEC3, a host factor that restricts the replication of exogenous retrovirus, is abundantly expressed in virus-resistant C57BL/6 (B6) mice. We have found that loss of APOBEC3 causes spontaneous mammary carcinoma and T cell lymphomas in B6 mice. The transcripts of endogenous mouse mammary tumor virus are abundant in the tumor cells prepared from APOBEC3-deficient mice. These results suggest that APOBEC3 contributes to the control of activated endogenous retrovirus.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：基盤研究(C);  研究期間：：2010～2012;   課題番号：22590352;   研究分野：医歯薬学;   科研費の分科・細目：基礎医学・実験病理学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/60297629.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/60167757.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/30344500.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAWAHARA, SACHIYO"},{"subitem_text_language":"en","subitem_text_value":"MIYAZAWA, MASAAKI"},{"subitem_text_language":"en","subitem_text_value":"HAKATA, YOSHIYUKI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部: 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河原,  佐智代"},{"creatorName":"カワハラ, サチヨ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"宮澤,  正顯"},{"creatorName":"ミヤザワ, マサアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"博多,  義之"},{"creatorName":"ハカタ, ヨシユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22590352seika.pdf","filesize":[{"value":"421.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22590352seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3554/files/KAKEN_22590352seika.pdf"},"version_id":"658d038c-a1ca-4039-b07e-8caf0831d9b7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"発がん制御","subitem_subject_scheme":"Other"},{"subitem_subject":"内在性レトロウイルス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"APOBEC3欠損によるリンパ腫発生機構の解析–-内在性レトロウイルスとの関連性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"APOBEC3欠損によるリンパ腫発生機構の解析–-内在性レトロウイルスとの関連性"}]},"item_type_id":"8","owner":"3","path":["2683","2684"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-25"},"publish_date":"2013-07-25","publish_status":"0","recid":"3554","relation_version_is_last":true,"title":["APOBEC3欠損によるリンパ腫発生機構の解析–-内在性レトロウイルスとの関連性"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:31:43.945667+00:00"}