{"created":"2023-06-20T16:34:22.473831+00:00","id":3553,"links":{},"metadata":{"_buckets":{"deposit":"0e404a06-22c1-44b4-9171-7ffe84d4fbd7"},"_deposit":{"created_by":3,"id":"3553","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3553"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003553","sets":["14:2667:2675:2679:2683","21:2669:2677:2681:2684"]},"author_link":["4243","4245","4246","4244"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The glycosyltransferase gene cluster associated with the circadian rhythm expression change in the suprachiasmatic nucleus"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 我々記述のようにシアル酸転移酵素ST8SiaⅥ 遺伝子の発現が視交叉上核SCN, 海馬HC に特異的かつ限局的に発現しており糖鎖関連遺伝子のST8SiaⅥ遺伝子が概日リズムと関連していることは明暗条件（ＺＴ）で飼育したマウスで、遺伝子発現に周期性があることを発見した。さらに、恒暗条件下で飼育したマウスでのST8SiaⅥ遺伝子が概日リズムと関連していることは不明であったため、その結果を得るために、恒暗条件下（ＣＴ）で飼育したマウスのST8SiaⅥ遺伝子発現の解析を行い、ＺＴ条件下と同様に概日リズムと関連していることを明らかにした。   研究成果の概要（英文）：Polysialic acids are implicated in various biological processes such as neural cell migration, axonal growth,synaptogenesis and resetting of the circadian rhythm. Recently, polysialation has been reported to beinvolved in the formation and resetting of the circadian clock. However, the genes that control thecircadian rhythm of polysialation have not been elucidated. In the present study, we investigated the expression profile of ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 (ST8Sia VI) in thesuprachiasmatic nucleus (SCN), which is one of the modification transferases that add sialic acids to type O carbohydrate chains. ST8Sia VI mRNA showed strong expression in the SCN with dynamic circadianhythm . Further, the amount of ST8Sia VI mRNA in the SCN was increased by brief light exposure. Interestingly,he localization of ST8Sia VI mRNA in the SCN differs from those of arginine vasopressin and vasoactive intestinal peptide mRNAs, which are typical SCN subregion markers showing shell and core, dorsomedial and ventrolateral, or light-responsive and unresponsive regions, respectively. The present findings suggest that ST8siVI is involved in rhythmic polysialation in the SCN and that ST8siVI expression provides a novel compartmentation of the mammalian circadian center.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：基盤研究（C）;  研究期間：2010～2012;   課題番号：22590232;   研究分野：医歯薬学;   科研費の分科・細目：基礎医学・環境生理学（含体力医学・栄養生理学）  ; SAIGOH, KAZUMASA","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/50319688.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/90195438.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/20275192.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/80368290.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SAIGO, KAZUMASA"},{"subitem_text_language":"en","subitem_text_value":"KUSUNOKI, SUSUMU"},{"subitem_text_language":"en","subitem_text_value":"SHIGEYOSHI, YASUFUMI"},{"subitem_text_language":"en","subitem_text_value":"HAYASAKA, NAOTO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西郷,  和真"},{"creatorName":"サイゴウ, カズマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"楠,  進"},{"creatorName":"クスノキ, ススム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"重吉,  康史"},{"creatorName":"シゲヨシ, ヤスフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"早坂,  直人"},{"creatorName":"ハヤサカ, ナオト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22590232seika.pdf","filesize":[{"value":"192.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22590232seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3553/files/KAKEN_22590232seika.pdf"},"version_id":"48b449c2-b8b2-40ec-bea4-789b42393962"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"睡眠・覚醒","subitem_subject_scheme":"Other"},{"subitem_subject":"睡眠障害","subitem_subject_scheme":"Other"},{"subitem_subject":"概日リズム","subitem_subject_scheme":"Other"},{"subitem_subject":"糖鎖遺伝子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"糖鎖転移酵素遺伝子群と視交叉上核における概日リズム発現変動について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖鎖転移酵素遺伝子群と視交叉上核における概日リズム発現変動について"}]},"item_type_id":"8","owner":"3","path":["2683","2684"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-25"},"publish_date":"2013-07-25","publish_status":"0","recid":"3553","relation_version_is_last":true,"title":["糖鎖転移酵素遺伝子群と視交叉上核における概日リズム発現変動について"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:31:46.182276+00:00"}