{"created":"2023-06-20T16:34:22.431695+00:00","id":3552,"links":{},"metadata":{"_buckets":{"deposit":"7aec12c2-78ff-4b2a-a09b-54b1c5676f39"},"_deposit":{"created_by":3,"id":"3552","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3552"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003552","sets":["14:2667:2675:2679:2683","21:2669:2677:2681:2684"]},"author_link":["4241","4240","4242","4238","4239"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of vascular remodeling by t-PA/t-PAR system"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：：作成したt-PAR過剰発現血管内皮細胞は、t-PA結合能、Plg活性化能、細胞増殖能、細胞浸潤・遊走能および管腔形成能が増強した。また、血管平滑筋細胞は、t-PA結合能とt-PAによるPlg活性化促進性を示した。それらの細胞におけるt-PA/t-PAR系は、組織障害後の修復・再生過程に重要な役割を果たすことが示唆された。    研究成果の概要（英文）：t-PAR-transfected endothelial cells enhanced the t-PA binding ability, t-PA-mediated plasminogen activation, migration and invasion of cells, and tube formation as compared with control endothelial cells. Vascular smooth muscle cells bound to t-PA and enhanced t-PA-mediated plasminogen activation. Therefore, it is thought that t-PA/t-PAR system on the membrane surface of these cells plays an important role on the tissue regeneration process.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：基盤研究（C）;  研究期間：2010～2012;   課題番号：22590219;   研究分野：医歯薬学;   科研費の分科・細目：基礎医学・生理学一般","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/40030879.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/30193791.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/20185432.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/70388510.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/90260281.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MATSUO, OSAMU"},{"subitem_text_language":"en","subitem_text_value":"UESHIMA, SHIGERU"},{"subitem_text_language":"en","subitem_text_value":"OKADA, KIYOTAKA"},{"subitem_text_language":"en","subitem_text_value":"KAWAO, NAOYUKI"},{"subitem_text_language":"en","subitem_text_value":"NAGAI, NOBUYUKI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 顧問"},{"subitem_text_value":"近畿大学農学部: 教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"長浜バイオ大学アニマルバイオサイエンス学科; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松尾,  理"},{"creatorName":"マツオ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"上嶋,  繁"},{"creatorName":"ウエシマ, シゲル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡田,  清孝"},{"creatorName":"オカダ, キヨタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河尾,  直之"},{"creatorName":"カワオ, ナオユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"永井,  信行"},{"creatorName":"ナガイ, ノブユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22590219seika.pdf","filesize":[{"value":"617.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22590219seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3552/files/KAKEN_22590219seika.pdf"},"version_id":"0928e849-3fa2-416f-b1ab-b091c5f9c850"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"血液凝固","subitem_subject_scheme":"Other"},{"subitem_subject":"血液レオロジー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ｔ-PA/ｔ-PAR系による血管修復・再生機能の解析とその応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ｔ-PA/ｔ-PAR系による血管修復・再生機能の解析とその応用"}]},"item_type_id":"8","owner":"3","path":["2683","2684"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-25"},"publish_date":"2013-07-25","publish_status":"0","recid":"3552","relation_version_is_last":true,"title":["ｔ-PA/ｔ-PAR系による血管修復・再生機能の解析とその応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:31:49.419349+00:00"}