{"created":"2023-06-20T16:34:20.799652+00:00","id":3522,"links":{},"metadata":{"_buckets":{"deposit":"c87836e9-0970-493f-b077-b9c87a6b3328"},"_deposit":{"created_by":3,"id":"3522","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3522"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003522","sets":["14:2667:2675:2679:2683","21:2669:2677:2681:2684"]},"author_link":["4177"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Molecular mechanism of bacterial signal transduction"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 細菌は環境変化を迅速に感知する多様な膜センサーを介して、環境適応に必要な遺伝子の発現を制御し、多様な環境変化に迅速に適応するシステム(TCS, two component signal transduction)を有している。細菌細胞は、1細胞に何十というTCS回路を持っていることが知られている。さらに、各TCS回路は互いに連結して、さらに複雑な遺伝子発現制御ネットワークを形成している。本研究では、世界で初めて、大腸菌K-12のTCS EvgS/EvgAとPhoQ/PhoPに着目して、それらの2種のTCS間をつなぐ、コネクターの働きを明らかにし、環境変化に迅速に適応できる細菌の情報伝達ネットワークの分子機構を明らかにした。           研究成果の概要（英文）：Bacteria have evolved two-component signal transduction systems (TCS), which are comprised of sensor histidine kinases (HK) and their cognate response regulators (RR, transcriptional factor). Bacterial cells have a number of TCSs to respond tovarious environmental stresses. Comprehensive transcriptome studies of these TCSs suggest that they interact with each other by means of a signal transduction network. In Escherichia call cells, we have clarified the molecular mechanism of how EvgS/EvgA TCS connects to PhoQ/PhoP TCS via a connector SafA.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：基盤研究(A);   研究期間：2008～2012;    課題番号：20248012;   研究分野：農学;   科研費の分科・細目：農芸化学　応用生物化学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/20151912.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"UTSUMI, RYUTARO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内海,  龍太郎"},{"creatorName":"ウツミ, リュウタロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20248012seika.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20248012seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3522/files/KAKEN_20248012seika.pdf"},"version_id":"b9d2065e-7f2e-4ed0-ab37-7e3f210b80b7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"two-component system","subitem_subject_scheme":"Other"},{"subitem_subject":"SafA","subitem_subject_scheme":"Other"},{"subitem_subject":"EvgS/EvgA","subitem_subject_scheme":"Other"},{"subitem_subject":"PhoQ/PhoP","subitem_subject_scheme":"Other"},{"subitem_subject":"connector","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細菌情報伝達ネットワークの分子機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細菌情報伝達ネットワークの分子機構"}]},"item_type_id":"8","owner":"3","path":["2683","2684"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-25"},"publish_date":"2013-07-25","publish_status":"0","recid":"3522","relation_version_is_last":true,"title":["細菌情報伝達ネットワークの分子機構"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:32:45.062487+00:00"}