{"created":"2023-06-20T16:34:20.754876+00:00","id":3521,"links":{},"metadata":{"_buckets":{"deposit":"8dbcb1da-90a7-401f-84f3-48220d64ee75"},"_deposit":{"created_by":3,"id":"3521","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3521"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003521","sets":["14:2667:2675:2679:2680","21:2669:2677:2681:2682"]},"author_link":["3351"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Molecular mechanisms uniderlying the reprogramming process of the totipotent fertilized eggs in mammals"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文): 生物個体を構成する200種類以上の細胞に自律的に分化できる能力(全能性)を持つ細胞は受精卵と一部の初期胚に限定されている。しかしながら、全能性の分子制御機構は、未だ解明されていない。本研究では、未受精卵・受精卵・初期胚の経時的な差次的プロテオーム解析により、全能性の獲得・維持・喪失と関連すると考えられる時期に発現量が変化するタンパク質を同定し、タンパク質の分子ネットワークの基礎的知見を獲得した。研究成果の概要(英文) : After fertilization, erasure of the oogenic program and reprogramming by establishing the embryonic programs into totipotent zygote are co-ordinately regulated. However, molecular mechanisms underlying the reprogramming process are not well understood. Understanding of the involvement of proteins in the degradation of maternal mRNA and proteins, and also the onset of ZGA at the maternal-to-zygotic transition helps elucidate molecular mechanisms governing the remodeling of the oocyte into the totipotent zygote and may also have implications for regulation of pluripotency.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号:34419;   研究種目：挑戦的萌芽研究;   研究期間：2011～2012;   課題番号：23658292;   研究分野：農学;   科研費の分科・細目：境界農学・応用分子細胞生物学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/20298938.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MATSUMOTO, KAZUYA"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学生物理工学部; 教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松本,  和也"},{"creatorName":"マツモト, カズヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_23658292seika.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23658292seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3521/files/KAKEN_23658292seika.pdf"},"version_id":"f3181163-fba6-4046-afce-f8a4d634b313"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"分化全能性","subitem_subject_scheme":"Other"},{"subitem_subject":"受精卵","subitem_subject_scheme":"Other"},{"subitem_subject":"初期胚","subitem_subject_scheme":"Other"},{"subitem_subject":"リプログラミング","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテオーム","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"哺乳動物初期胚における全能性の分子制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"哺乳動物初期胚における全能性の分子制御機構の解明"}]},"item_type_id":"8","owner":"3","path":["2680","2682"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-19"},"publish_date":"2013-07-19","publish_status":"0","recid":"3521","relation_version_is_last":true,"title":["哺乳動物初期胚における全能性の分子制御機構の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:32:45.982091+00:00"}