{"created":"2023-06-20T16:34:20.449090+00:00","id":3514,"links":{},"metadata":{"_buckets":{"deposit":"a87f43a8-7ed6-494f-8728-1a764d14f5ac"},"_deposit":{"created_by":3,"id":"3514","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3514"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003514","sets":["14:2667:2675:2679:2680","21:2669:2677:2681:2682"]},"author_link":["3128"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Early prediction of senile cataract based on the elucidation of mitochondrial DNA"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文):急速かつ強いレベルの酸化的刺激は、ヒト水晶体上皮においてミトコンドリア傷害を引き起こすこと、また、この傷害には、刺激に対するミトコンドリアの感受性に加え、細胞膜の反応性・抵抗性が密接に関わることを明らかとした。さらに、これらミトコンドリア機能低下は、早期において可逆的であるが、機能回復には時間を有することを見出した。以上、一過性のミトコンドリア傷害の繰り返しは、水障体白濁に繋がる可能性を示した。        研究成果の概要(英文): We demonstrated that the rapidly and high production of nitric oxide (NO) caused to the mitochondreal damage in the human lens epithelial cells, and tbe balance in sensitivity of mitochondrisa and cell membrane to NO were related the mitochondrial dysfunction. In addition, the recovery time for mitochondrial function is related to exposure time to NO in human lens epitjelial cells. The repetition in temporary mitochondreal dysfunction may be caused  the lens opacification.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号: 34419;   研究種目：若手研究(B);   研究期間：2011～2012;   課題番号：23790678;   研究分野：医歯薬学;    科研費の分科・細目：衛生学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/90411579.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NAGAI, NORIAKI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長井,  紀章"},{"creatorName":"ナガイ, ノリアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3128","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90411579","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_23790678seika.pdf","filesize":[{"value":"768.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23790678seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3514/files/KAKEN_23790678seika.pdf"},"version_id":"790b943f-1d52-4eac-8d81-14d4e905b8cf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ミトコンドリアDNA","subitem_subject_scheme":"Other"},{"subitem_subject":"水晶体上皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"シトクロムcオキシダーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"白内障","subitem_subject_scheme":"Other"},{"subitem_subject":"一酸化窒素","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化的ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"ATP","subitem_subject_scheme":"Other"},{"subitem_subject":"Ca^<2+>-ATPase","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ミトコンドリアDNAの遺伝情報に基づいた加齢性白内障の素因と早期予測","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミトコンドリアDNAの遺伝情報に基づいた加齢性白内障の素因と早期予測"}]},"item_type_id":"8","owner":"3","path":["2680","2682"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-19"},"publish_date":"2013-07-19","publish_status":"0","recid":"3514","relation_version_is_last":true,"title":["ミトコンドリアDNAの遺伝情報に基づいた加齢性白内障の素因と早期予測"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:32:58.932632+00:00"}